Inflammation is one of the most characteristic features of chronic liver disease of viral,
alcoholic, fatty, and autoimmune origin. Inflammation is typically present in all disease …

Hepatic cirrhosis and hepatocellular carcinoma (HCC) are the most common causes of
death in patients with chronic liver disease. Chronic liver injury of virtually any etiology …

Chronic inflammation is associated with normal and pathological ageing. Here we show that
chronic, progressive low-grade inflammation induced by knockout of the nfkb1 subunit of the …

The p53 tumor suppressor can restrict malignant transformation by triggering cell-
autonomous programs of cell-cycle arrest or apoptosis. p53 also promotes cellular …

The hepatic stellate cell has surprised and engaged physiologists, pathologists, and
hepatologists for over 130 years, yet clear evidence of its role in hepatic injury and fibrosis …

The pleiotropic consequences of nuclear factor of kappa light polypeptide gene enhancer in
B‐cells (NF‐κB) pathway activation result from the combinatorial effects of the five subunits …

Aging is associated with impaired tissue regeneration. Stem cell number and function have
been identified as potential culprits. We first demonstrate a direct correlation between stem …

Pulmonary hypertension (PH) is a deadly vascular disease with enigmatic molecular origins.
We found that vascular extracellular matrix (ECM) remodeling and stiffening are early and …

BACKGROUND & AIMS: Myofibroblast transdifferentiation generates hepatic myofibroblasts,
which promote liver fibrogenesis. The peroxisome proliferator-activated receptor γ (PPARγ) …

We investigated whether ancestral liver damage leads to heritable reprogramming of
hepatic wound healing in male rats. We found that a history of liver damage corresponds …