The genetics of depression: a review
DF Levinson - Biological psychiatry, 2006 - Elsevier
Major depressive disorder (MDD) is common and moderately heritable. Recurrence and
early age at onset characterize cases with the greatest familial risk. Major depressive …
early age at onset characterize cases with the greatest familial risk. Major depressive …
The BDNF gene Val66Met polymorphism as a modifier of psychiatric disorder susceptibility: progress and controversy
Brain-derived neurotrophic factor (BDNF) has a primary role in neuronal development,
differentiation and plasticity in both the develo** and adult brain. A single-nucleotide …
differentiation and plasticity in both the develo** and adult brain. A single-nucleotide …
Brain‐derived neurotrophic factor as a biomarker for mood disorders: an historical overview and future directions
K Hashimoto - Psychiatry and clinical neurosciences, 2010 - Wiley Online Library
Mood disorders, such as major depressive disorder (MDD) and bipolar disorder (BPD), are
the most prevalent psychiatric conditions, and are also among the most severe and …
the most prevalent psychiatric conditions, and are also among the most severe and …
Pharmacogenetics of antidepressants and antipsychotics: the contribution of allelic variations to the phenotype of drug response
Genetic factors contribute to the phenotype of drug response. We systematically analyzed all
available pharmacogenetic data from Medline databases (1970–2003) on the impact that …
available pharmacogenetic data from Medline databases (1970–2003) on the impact that …
Brain-derived neurotrophic factor: role in depression and suicide
Y Dwivedi - Neuropsychiatric disease and treatment, 2009 - Taylor & Francis
Depression and suicidal behavior have recently been shown to be associated with
disturbances in structural and synaptic plasticity. Brain-derived neurotrophic factor (BDNF) …
disturbances in structural and synaptic plasticity. Brain-derived neurotrophic factor (BDNF) …
Recent developments and current controversies in depression
In this review of the last 5 years' developments in research into depression we focus on
recent advances and current controversies. We cover epidemiology and basic science as …
recent advances and current controversies. We cover epidemiology and basic science as …
Critical role of brain-derived neurotrophic factor in mood disorders
The purpose of this review is to integrate what is currently known about the role of brain-
derived neurotrophic factor (BDNF) in the pathophysiology of mood disorders including …
derived neurotrophic factor (BDNF) in the pathophysiology of mood disorders including …
Meta-analysis of the BDNF Val66Met polymorphism in major depressive disorder: effects of gender and ethnicity
M Verhagen, A Van Der Meij, PAM Van Deurzen… - Molecular …, 2010 - nature.com
Brain-derived neurotrophic factor (BDNF) is a nerve growth factor that has antidepressant-
like effects in animals and may be implicated in the etiology of mood-related phenotypes …
like effects in animals and may be implicated in the etiology of mood-related phenotypes …
Multi-target strategies for the improved treatment of depressive states: conceptual foundations and neuronal substrates, drug discovery and therapeutic application
MJ Millan - Pharmacology & therapeutics, 2006 - Elsevier
Major depression is a debilitating and recurrent disorder with a substantial lifetime risk and a
high social cost. Depressed patients generally display co-morbid symptoms, and depression …
high social cost. Depressed patients generally display co-morbid symptoms, and depression …
Is it time to reassess the BDNF hypothesis of depression?
JO Groves - Molecular psychiatry, 2007 - nature.com
The brain-derived neurotrophic factor (BDNF) hypothesis of depression postulates that a
loss of BDNF is directly involved in the pathophysiology of depression, and that its …
loss of BDNF is directly involved in the pathophysiology of depression, and that its …