Clonal expansions of mutated hematopoietic cells, termed clonal hematopoiesis, are
common in aging humans. One expected consequence of mutation-associated clonal …

Clonal hematopoiesis (CH) is common in older persons and is associated with an increased
risk of hematologic cancer. Here, we review studies establishing an association between CH …

We sought to determine the significance of myeloid clonal hematopoiesis (CH) in the UK
Biobank cohort (n= 502,524, median age= 58 years). Utilizing SNP array (n= 486,941) and …

Mutations in genes that confer a selective advantage to hematopoietic stem cells (HSCs)
drive clonal hematopoiesis (CH). While some CH drivers have been identified, the …

Acquired genetic mutations in hematopoietic stem or progenitor cells can lead to clonal
expansion and imbalanced blood cell production. Clonal hematopoiesis is exceptionally …

Chemotherapies may increase mutagenesis of healthy cells and change the selective
pressures in tissues, thus influencing their evolution. However, their contributions to the …

Studies of therapy-related AML (t-AML) are usually performed in selected cohorts and
reliable incidence rates are lacking. In this study, we characterized, defined the incidence …

Background The widespread adoption of high throughput technologies has democratized
data generation. However, data processing in accordance with best practices remains …

Clonal hematopoiesis (CH) occurs when blood cells harboring an advantageous mutation
propagate faster than others. These mutations confer a risk for hematological cancers and …

The changing landscape of treatment options for multiple myeloma has led to a higher
proportion of patients achieving deep, long-lasting responses to therapy. With the …