Exploring the potential of genome editing CRISPR-Cas9 technology
CRISPR-Cas9 is an RNA-mediated adaptive immune system that protects bacteria and
archaea from viruses or plasmids. Herein we discuss the recent development of CRISPR …
archaea from viruses or plasmids. Herein we discuss the recent development of CRISPR …
The molecular genetics of mycolic acid biosynthesis
J Pawełczyk, L Kremer - Molecular Genetics of Mycobacteria, 2014 - Wiley Online Library
The mycobacterial cell wall is essential for Mycobacterium tuberculosis growth and survival.
It is lipid‐rich and highly impermeable and thereby provides protection from many …
It is lipid‐rich and highly impermeable and thereby provides protection from many …
Chemico-pharmacological evaluations of the dwarf elephant ear (Colocasia affinis Schott) plant metabolites and extracts: health benefits from vegetable source
Introduction: Colocasia affinis Schott (Family: Araceae), found in the Asian region, is a
traditional root vegetable consumed by the locals and well-known as Dwarf Elephant Ear …
traditional root vegetable consumed by the locals and well-known as Dwarf Elephant Ear …
Resuscitation of Dormant “Non-culturable” Mycobacterium tuberculosis Is Characterized by Immediate Transcriptional Burst
EG Salina, AS Grigorov, OS Bychenko… - Frontiers in cellular …, 2019 - frontiersin.org
Under unfavorable conditions such as host immune responses and environmental stresses,
human pathogen Mycobacterium tuberculosis may acquire the dormancy phenotype …
human pathogen Mycobacterium tuberculosis may acquire the dormancy phenotype …
Advances in mycobacterial isocitrate lyase targeting and inhibitors
M Kratky, J Vinsova - Current medicinal chemistry, 2012 - ingentaconnect.com
Isocitrate lyase plays a key role for survival of Mycobacterium tuberculosis in the latent form
during a chronic stage of infection. This enzyme is important for M. tuberculosis during …
during a chronic stage of infection. This enzyme is important for M. tuberculosis during …
Association between fatty acid metabolism gene mutations and Mycobacterium tuberculosis transmission revealed by whole genome sequencing
Y Li, X Kong, Y Li, N Tao, T Wang, Y Li, Y Hou, X Zhu… - BMC microbiology, 2023 - Springer
Background Fatty acid metabolism greatly promotes the virulence and pathogenicity of
Mycobacterium tuberculosis (M. tb). However, the regulatory mechanism of fatty acid …
Mycobacterium tuberculosis (M. tb). However, the regulatory mechanism of fatty acid …
Cytosolic Proteome Profiling of Aminoglycosides Resistant Mycobacterium tuberculosis Clinical Isolates Using MALDI-TOF/MS
D Sharma, M Lata, R Singh, N Deo… - Frontiers in …, 2016 - frontiersin.org
Emergence of extensively drug resistant tuberculosis (XDR-TB) is the consequence of the
failure of second line TB treatment. Aminoglycosides are the important second line anti-TB …
failure of second line TB treatment. Aminoglycosides are the important second line anti-TB …
(E)‐2‐(2‐Allylidenehydrazinyl)thiazole derivatives: Design, green synthesis, in silico and in vitro antimycobacterial and radical scavenging studies
By understanding the rampant infections of Mycobacterium tuberculosis (Mtb) and
inflammations caused due to the generation of radical species during the Mtb infection, a …
inflammations caused due to the generation of radical species during the Mtb infection, a …
Genome analyses of 174 strains of Mycobacterium tuberculosis provide insight into the evolution of drug resistance and reveal potential drug targets
Mycobacterium tuberculosis is a known human pathogen that causes the airborne infectious
disease tuberculosis (TB). Every year TB infects millions of people worldwide. The …
disease tuberculosis (TB). Every year TB infects millions of people worldwide. The …
Core proteome mediated subtractive approach for the identification of potential therapeutic drug target against the honeybee pathogen Paenibacillus larvae
Methods We investigated effective novel drug targets through a comprehensive in silico pan-
proteome and hierarchal subtractive sequence analysis. In total, 14 strains of P. larvae …
proteome and hierarchal subtractive sequence analysis. In total, 14 strains of P. larvae …