Advances in therapeutic applications of extracellular vesicles

OPB Wiklander, MÁ Brennan, J Lötvall… - Science translational …, 2019 - science.org
Extracellular vesicles (EVs) are nanometer-sized, lipid membrane–enclosed vesicles
secreted by most, if not all, cells and contain lipids, proteins, and various nucleic acid …

Exploiting the biogenesis of extracellular vesicles for bioengineering and therapeutic cargo loading

J Rädler, D Gupta, A Zickler, SEL Andaloussi - Molecular Therapy, 2023 - cell.com
Extracellular vesicles (EVs) are gaining increasing attention for diagnostic and therapeutic
applications in various diseases. These natural nanoparticles benefit from favorable safety …

Challenges in exosome isolation and analysis in health and disease

N Ludwig, TL Whiteside, TE Reichert - International journal of molecular …, 2019 - mdpi.com
A growing body of evidence emphasizes the important role exosomes in different
physiological and pathological conditions. Exosomes, virus-size extracellular vesicles (EVs) …

Methods of the large-scale production of extracellular vesicles

V Syromiatnikova, A Prokopeva… - International Journal of …, 2022 - mdpi.com
To date, extracellular vesicles (EVs) have been extensively investigated as potential
substitutes for cell therapy. Research has suggested their ability to overcome serious risks …

Technological advances towards extracellular vesicles mass production

A Grangier, J Branchu, J Volatron, M Piffoux… - Advanced Drug Delivery …, 2021 - Elsevier
Extracellular vesicles (EVs) are becoming essential actors in bio-therapeutics, as much for
their regenerative or immunomodulatory properties as for their potential as cargo delivery …

Biogenesis, composition and potential therapeutic applications of mesenchymal stem cells derived exosomes in various diseases

YG Yuan, JL Wang, YX Zhang, L Li… - International Journal …, 2023 - Taylor & Francis
Exosomes are nanovesicles with a wide range of chemical compositions used in many
different applications. Mesenchymal stem cell-derived exosomes (MSCs-EXOs) are …

Biological functions driven by mRNAs carried by extracellular vesicles in cancer

M Prieto-Vila, Y Yoshioka, T Ochiya - Frontiers in Cell and …, 2021 - frontiersin.org
Extracellular vesicles (EVs), including exosomes and microvesicles, are extracellular
nanovesicles released by most cells. EVs play essential roles in intercellular communication …

Small extracellular vesicles: a novel avenue for cancer management

Y Gao, Y Qin, C Wan, Y Sun, J Meng, J Huang… - Frontiers in …, 2021 - frontiersin.org
Extracellular vesicles are small membrane particles derived from various cell types. EVs are
broadly classified as ectosomes or small extracellular vesicles, depending on their …

Systematic review of exosome treatment in hair restoration: Preliminary evidence, safety, and future directions

AK Gupta, T Wang, JA Rapaport - Journal of Cosmetic …, 2023 - Wiley Online Library
Background Exosomes are small extracellular vesicles with potential roles in modulating the
hair growth cycle and are an emerging therapy for patients with alopecia. In recent years …

Applications, challenges and prospects of mesenchymal stem cell exosomes in regenerative medicine

A Rezabakhsh, E Sokullu, R Rahbarghazi - Stem Cell Research & …, 2021 - Springer
Recent advances in the identification and application of different stem cell types have
offered alternative therapeutic approaches for clinicians. The lack of successful engraftment …