MAPK-activated protein kinases: servant or partner?
N Ronkina, M Gaestel - Annual review of biochemistry, 2022 - annualreviews.org
Mitogen-activated protein kinase (MAPK)-activated protein kinases (MAPKAPKs) are
defined by their exclusive activation by MAPKs. They can be activated by classical and …
defined by their exclusive activation by MAPKs. They can be activated by classical and …
Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints
A Sancar, LA Lindsey-Boltz… - Annual review of …, 2004 - annualreviews.org
▪ Abstract DNA damage is a relatively common event in the life of a cell and may lead to
mutation, cancer, and cellular or organismic death. Damage to DNA induces several cellular …
mutation, cancer, and cellular or organismic death. Damage to DNA induces several cellular …
Cell-cycle checkpoints and cancer
MB Kastan, J Bartek - Nature, 2004 - nature.com
All life on earth must cope with constant exposure to DNA-damaging agents such as the
Sun's radiation. Highly conserved DNA-repair and cell-cycle checkpoint pathways allow …
Sun's radiation. Highly conserved DNA-repair and cell-cycle checkpoint pathways allow …
[HTML][HTML] p38 MAP-kinases pathway regulation, function and role in human diseases
A Cuenda, S Rousseau - Biochimica et Biophysica Acta (BBA)-Molecular …, 2007 - Elsevier
Mammalian p38 mitogen-activated protein kinases (MAPKs) are activated by a wide range
of cellular stresses as well as in response to inflammatory cytokines. There are four …
of cellular stresses as well as in response to inflammatory cytokines. There are four …
Mitogen-activated protein kinases in apoptosis regulation
T Wada, JM Penninger - Oncogene, 2004 - nature.com
Cells are continuously exposed to a variety of environmental stresses and have to decide 'to
be or not to be'depending on the types and strength of stress. Among the many signaling …
be or not to be'depending on the types and strength of stress. Among the many signaling …
Differential regulation and properties of MAPKs
M Raman, W Chen, MH Cobb - Oncogene, 2007 - nature.com
Mitogen-activated protein kinases (MAPKs) regulate diverse cellular programs including
embryogenesis, proliferation, differentiation and apoptosis based on cues derived from the …
embryogenesis, proliferation, differentiation and apoptosis based on cues derived from the …
DRUG-seq for miniaturized high-throughput transcriptome profiling in drug discovery
C Ye, DJ Ho, M Neri, C Yang, T Kulkarni… - Nature …, 2018 - nature.com
Here we report Digital RNA with pertUrbation of Genes (DRUG-seq), a high-throughput
platform for drug discovery. Pharmaceutical discovery relies on high-throughput screening …
platform for drug discovery. Pharmaceutical discovery relies on high-throughput screening …
Cellular response to hyperosmotic stresses
MB Burg, JD Ferraris, NI Dmitrieva - Physiological reviews, 2007 - journals.physiology.org
Cells in the renal inner medulla are normally exposed to extraordinarily high levels of NaCl
and urea. The osmotic stress causes numerous perturbations because of the hypertonic …
and urea. The osmotic stress causes numerous perturbations because of the hypertonic …
Phosphatase‐mediated crosstalk between MAPK signaling pathways in the regulation of cell survival
MR Junttila, SP Li, J Westermarck - The FASEB Journal, 2008 - Wiley Online Library
Mitogen‐activated protein kinase (MAPK) pathways constitute a large modular network that
regulates a variety of physiological processes, such as cell growth, differentiation, and …
regulates a variety of physiological processes, such as cell growth, differentiation, and …
CDC25 phosphatases in cancer cells: key players? Good targets?
R Boutros, V Lobjois, B Ducommun - Nature Reviews Cancer, 2007 - nature.com
Abstract Cell division cycle 25 (CDC25) phosphatases regulate key transitions between cell
cycle phases during normal cell division, and in the event of DNA damage they are key …
cycle phases during normal cell division, and in the event of DNA damage they are key …