This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

Transient receptor potential vanilloid type 4 (TRPV4) is a calcium-permeable nonselective
cation channel, originally described in 2000 by research teams led by Schultz (Nat Cell Biol …

The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …

A diverse array of environmental factors contributes to the overall control of stem cell activity.
In particular, new data continue to mount on the influence of the extracellular matrix (ECM) …

The mechanically activated non-selective cation channel Piezo1 is a determinant of vascular
architecture during early development. Piezo1-deficient embryos die at midgestation with …

The ability to control cell volume is pivotal for cell function. Cell volume perturbation elicits a
wide array of signaling events, leading to protective (eg, cytoskeletal rearrangement) and …

Many ion channels have been described as mechanosensitive according to various criteria.
Most broadly defined, an ion channel is called mechanosensitive if its activity is controlled by …

Transient receptor potential (TRP) channels are important mediators of sensory signals with
marked effects on cellular functions and signalling pathways. Indeed, mutations in genes …

The urothelium is a sensory structure that contributes to mechanosensation in the urinary
bladder. Here, we provide evidence for a critical role for the Piezo1 channel, a newly …

The Transient Receptor Potential Vanilloid 4 channel, TRPV4, is a Ca2+ and Mg2+
permeable non-selective cation channel involved in many different cellular functions. It is …