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Next-generation sequencing in oncology: genetic diagnosis, risk prediction and cancer classification
R Kamps, RD Brandão, BJ van den Bosch… - International journal of …, 2017 - mdpi.com
Next-generation sequencing (NGS) technology has expanded in the last decades with
significant improvements in the reliability, sequencing chemistry, pipeline analyses, data …
significant improvements in the reliability, sequencing chemistry, pipeline analyses, data …
Unraveling metagenomics through long-read sequencing: a comprehensive review
The study of microbial communities has undergone significant advancements, starting from
the initial use of 16S rRNA sequencing to the adoption of shotgun metagenomics. However …
the initial use of 16S rRNA sequencing to the adoption of shotgun metagenomics. However …
Origin and evolution of the octoploid strawberry genome
Cultivated strawberry emerged from the hybridization of two wild octoploid species, both
descendants from the merger of four diploid progenitor species into a single nucleus more …
descendants from the merger of four diploid progenitor species into a single nucleus more …
Comparative analysis between 2D and 3D colorectal cancer culture models for insights into cellular morphological and transcriptomic variations
Drug development is a time-consuming and expensive process, given the low success rate
of clinical trials. Now, anticancer drug developments have shifted to three-dimensional (3D) …
of clinical trials. Now, anticancer drug developments have shifted to three-dimensional (3D) …
A chromosome-based draft sequence of the hexaploid bread wheat (Triticum aestivum) genome
International Wheat Genome Sequencing Consortium … - Science, 2014 - science.org
An ordered draft sequence of the 17-gigabase hexaploid bread wheat (Triticum aestivum)
genome has been produced by sequencing isolated chromosome arms. We have annotated …
genome has been produced by sequencing isolated chromosome arms. We have annotated …
Efficient derivation of stable primed pluripotent embryonic stem cells from bovine blastocysts
Embryonic stem cells (ESCs) are derived from the inner cell mass of preimplantation
blastocysts. From agricultural and biomedical perspectives, the derivation of stable ESCs …
blastocysts. From agricultural and biomedical perspectives, the derivation of stable ESCs …
Neuro-mesenchymal units control ILC2 and obesity via a brain–adipose circuit
F Cardoso, RGJ Klein Wolterink, C Godinho-Silva… - Nature, 2021 - nature.com
Signals from sympathetic neurons and immune cells regulate adipocytes and thereby
contribute to fat tissue biology. Interactions between the nervous and immune systems have …
contribute to fat tissue biology. Interactions between the nervous and immune systems have …
Linking chromatin acylation mark-defined proteome and genome in living cells
A generalizable strategy with programmable site specificity for in situ profiling of histone
modifications on unperturbed chromatin remains highly desirable but challenging. We …
modifications on unperturbed chromatin remains highly desirable but challenging. We …
Plasma cell-free RNA profiling distinguishes cancers from pre-malignant conditions in solid and hematologic malignancies
Cell-free RNA (cfRNA) in plasma reflects phenotypic alterations of both localized sites of
cancer and the systemic host response. Here we report that cfRNA sequencing enables the …
cancer and the systemic host response. Here we report that cfRNA sequencing enables the …
Computational prediction and validation of tumor-associated neoantigens
V Roudko, B Greenbaum, N Bhardwaj - Frontiers in Immunology, 2020 - frontiersin.org
Tumor progression is typically accompanied by an accumulation of driver and passenger
somatic mutations. A handful of those mutations occur in protein coding genes which …
somatic mutations. A handful of those mutations occur in protein coding genes which …