Cancer is a multifactorial disease that is responsible for 10 million deaths per year. The intra-
and inter-heterogeneity of malignant tumors make it difficult to develop single targeted …

Cell therapy practices date back to the 19th century and continue to expand on
investigational and investment grounds. Cell therapy includes stem cell-and non–stem cell …

In nature, cells reside in tissues subject to complex cell–cell interactions, signals from
extracellular molecules and niche soluble and mechanical signaling. These …

Colorectal cancer (CRC) is the third most diagnosed malignancy and a major leading cause
of cancer-related deaths worldwide. Despite advances in therapeutic regimens, the number …

In the last decade, organoid research has entered a golden era, signifying a pivotal shift in
the biomedical landscape. The year 2023 marked a milestone with the publication of …

The paradigm of pediatric drug development has been evolving in a “carrot-and-stick”-based
tactic to address population-specific issues. However, the off-label prescription of adult …

Organoids are miniaturized and simplified versions of an organ produced in vitro from stem
or progenitor cells. They are used as a model system consisting of multiple cell types …

Cardiovascular disease is a significant cause of death in humans. Various models are
necessary for the study of cardiovascular diseases, but once cellular and animal models …

As the primary site for the biotransformation of drugs, the liver is the most focused on organ
type in pharmaceutical research. However, despite being widely used in pharmaceutical …

Engineered three-dimensional (3D) in vitro and ex vivo neural tissues, also known as “mini
brains and spinal cords in a dish,” can be derived from different types of human stem cells …