Status epilepticus is a life-threatening neurological emergency that affects both adults and
children. Approximately 36% of episodes of status epilepticus do not respond to the current …

Synaptic inhibition plays a crucial role in regulating neuronal excitability, which is the
foundation of nervous system function. This inhibition is largely mediated by the …

Objective To propose a new hypothesis that GABAergic dysfunction in excitatory and
inhibitory (E/I) imbalance drives the pathogenesis of Alzheimer's disease (AD). Background …

Neuronal chloride regulation is a determinant factor for the dynamic tuning of GABAergic
inhibition during and beyond brain development. This regulation is mainly dependent on the …

The chloride importer NKCC1 and the chloride exporter KCC2 are key regulators of
neuronal chloride concentration. A defective NKCC1/KCC2 expression ratio is associated …

Throughout early phases of brain development, the two main neural signaling mechanisms—
excitation and inhibition—are dynamically sculpted in the neocortex to establish primary …

Brain ischemia affects all ages, from neonates to the elderly population, and is a leading
cause of mortality and morbidity. Multiple preclinical rodent models involving different ages …

Epilepsy is a common neurological disorder associated with alterations of excitation‐
inhibition balance within brain neuronal networks. GABAA receptor neurotransmission is the …

Developmental, cellular, and subcellular variations in the direction of neuronal Cl–currents
elicited by GABA A receptor activation have been frequently reported. We found a …

Long-term synaptic plasticity is shaped by the controlled reorganization of the synaptic
proteome. A key component of this process is local proteolysis performed by the family of …