The mammalian target of rapamycin (mTOR) is a protein kinase that controls cellular
metabolism, catabolism, immune responses, autophagy, survival, proliferation, and …

Inhibition of the protein kinase mechanistic target of rapamycin (mTOR) with the Food and
Drug Administration (FDA)-approved therapeutic rapamycin promotes health and longevity …

Aging is associated with changes in circulating levels of various molecules, some of which
remain undefined. We find that concentrations of circulating taurine decline with aging in …

Lifespan varies within and across species, but the general principles of its control remain
unclear. Here, we conducted multi-tissue RNA-seq analyses across 41 mammalian species …

Ageing is inherent to all human beings, yet why we age remains a hotly contested topic.
Most mechanistic explanations of ageing posit that ageing is caused by the accumulation of …

With the rapid expansion of aging biology research, the identification and evaluation of
longevity interventions in humans have become key goals of this field. Biomarkers of aging …

We propose a two-mode (pursuit/maintenance) model of metabolism defined by usable
resource availability. Pursuit, consisting of anabolism and catabolism, dominates when …

Rapamycin (sirolimus) and other rapalogs (everolimus) are anti-cancer and anti-aging
drugs, which delay cancer by directly targeting pre-cancerous cells and, indirectly, by …

Abstract Machine learning models based on DNA methylation data can predict biological
age but often lack causal insights. By harnessing large-scale genetic data through …

Mitochondria are central to cellular energy production, and their dysfunction is a major
contributor to oxidative stress and chronic inflammation, pivotal factors in aging, and related …