▪ Abstract The matrix metalloproteinases (MMPs) constitute a multigene family of over 25
secreted and cell surface enzymes that process or degrade numerous pericellular …

Tumor progression is a complex, multistage process by which a normal cell undergoes
genetic changes that result in phenotypic alterations and the acquisition of the ability to …

It is now becoming apparent that dynamic changes occur within the interstitium that directly
contribute to adverse myocardial remodeling following myocardial infarction (MI), with …

For more than two decades, the view that tumour-associated matrix metalloproteinases
(MMPs) were required for peritumour tissue degradation and metastasis dominated the drive …

Deleterious processes of extracellular proteolysis may contribute to the progression of tissue
damage after acute brain injury. We recently showed that matrix metalloproteinase-9 (MMP …

The metalloproteinases degrade extracellular matrix (ECM) components and activate growth
factors, thereby contributing to physiological events (tissue remodeling in pregnancy, wound …

Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes responsible for
myocardial extracellular protein degradation. Several MMP species identified within the …

Matrix metalloproteinases (MMPs) form a family of enzymes that mediate multiple functions
both in the tissue destruction and immune responses related to periodontal inflammation …

Extensive work on the mechanisms of tumor invasion and metastasis has identified matrix
metalloproteinases (MMPs) as key players in the events that underlie tumor dissemination …

The matrix metalloproteinases (MMPs) are a family of zinc-dependent proteinases involved
in the degradation of the extracellular matrix. The MMPs have been implicated in the …