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Neuroinflammation in Alzheimer disease
Increasing evidence points to a pivotal role of immune processes in the pathogenesis of
Alzheimer disease, which is the most prevalent neurodegenerative and dementia-causing …
Alzheimer disease, which is the most prevalent neurodegenerative and dementia-causing …
Chronic traumatic encephalopathy (CTE): criteria for neuropathological diagnosis and relationship to repetitive head impacts
Over the last 17 years, there has been a remarkable increase in scientific research
concerning chronic traumatic encephalopathy (CTE). Since the publication of NINDS–NIBIB …
concerning chronic traumatic encephalopathy (CTE). Since the publication of NINDS–NIBIB …
National Institute of Neurological Disorders and Stroke consensus diagnostic criteria for traumatic encephalopathy syndrome
Objective To develop evidence-informed, expert consensus research diagnostic criteria for
traumatic encephalopathy syndrome (TES), the clinical disorder associated with …
traumatic encephalopathy syndrome (TES), the clinical disorder associated with …
Microglia in neurodegeneration
The neuroimmune system is involved in development, normal functioning, aging, and injury
of the central nervous system. Microglia, first described a century ago, are the main …
of the central nervous system. Microglia, first described a century ago, are the main …
Neuropathologic and clinical findings in young contact sport athletes exposed to repetitive head impacts
AC McKee, J Mez, B Abdolmohammadi… - JAMA …, 2023 - jamanetwork.com
Importance Young contact sport athletes may be at risk for long-term neuropathologic
disorders, including chronic traumatic encephalopathy (CTE). Objective To characterize the …
disorders, including chronic traumatic encephalopathy (CTE). Objective To characterize the …
New insights into the role of TREM2 in Alzheimer's disease
M Gratuze, CEG Leyns, DM Holtzman - Molecular neurodegeneration, 2018 - Springer
Alzheimer's disease (AD) is the leading cause of dementia. The two histopathological
markers of AD are amyloid plaques composed of the amyloid-β (Aβ) peptide, and …
markers of AD are amyloid plaques composed of the amyloid-β (Aβ) peptide, and …
The far-reaching scope of neuroinflammation after traumatic brain injury
DW Simon, MJ McGeachy, H Bayır, RSB Clark… - Nature Reviews …, 2017 - nature.com
The'silent epidemic'of traumatic brain injury (TBI) has been placed in the spotlight as a result
of clinical investigations and popular press coverage of athletes and veterans with single or …
of clinical investigations and popular press coverage of athletes and veterans with single or …
Neuroimmunology of traumatic brain injury: time for a paradigm shift
YN Jassam, S Izzy, M Whalen, DB McGavern… - Neuron, 2017 - cell.com
Traumatic brain injury (TBI) is a leading cause of morbidity and disability, with a
considerable socioeconomic burden. Heterogeneity of pathoanatomical subtypes and …
considerable socioeconomic burden. Heterogeneity of pathoanatomical subtypes and …
Clinicopathological evaluation of chronic traumatic encephalopathy in players of American football
J Mez, DH Daneshvar, PT Kiernan… - Jama, 2017 - jamanetwork.com
Importance Players of American football may be at increased risk of long-term neurological
conditions, particularly chronic traumatic encephalopathy (CTE). Objective To determine the …
conditions, particularly chronic traumatic encephalopathy (CTE). Objective To determine the …
Microglial depletion with CSF1R inhibitor during chronic phase of experimental traumatic brain injury reduces neurodegeneration and neurological deficits
RJ Henry, RM Ritzel, JP Barrett, SJ Doran… - Journal of …, 2020 - jneurosci.org
Chronic neuroinflammation with sustained microglial activation occurs following severe
traumatic brain injury (TBI) and is believed to contribute to subsequent neurodegeneration …
traumatic brain injury (TBI) and is believed to contribute to subsequent neurodegeneration …