Riboswitches are structured noncoding RNA domains used by many bacteria to monitor the
concentrations of target ligands and regulate gene expression accordingly. In the past 20 …

Riboswitches were discovered in 2002 in bacteria as RNA-based intracellular sensors of
vitamin derivatives. During the last decade, naturally occurring RNA sensor elements have …

A dynamic programming algorithm for prediction of RNA secondary structure has been
revised to accommodate folding constraints determined by chemical modification and to …

Although proteins fulfil most of the requirements that biology has for structural and functional
components such as enzymes and receptors, RNA can also serve in these capacities. For …

A growing collection of bacterial riboswitch classes is being discovered that sense central
metabolites, coenzymes, and signaling molecules. Included among the various mechanisms …

An expanding number of metabolite-binding riboswitch classes are being discovered in the
noncoding portions of bacterial genomes. Findings over the last decade indicate that …

Riboswitches are complex folded RNA domains that serve as receptors for specific
metabolites. These domains are found in the non-coding portions of various mRNAs, where …

Messenger RNAs are typically thought of as passive carriers of genetic information that are
acted upon by protein-or small RNA-regulatory factors and by ribosomes during the process …

Thiamin and riboflavin are precursors of essential coenzymes—thiamin pyrophosphate
(TPP) and flavin mononucleotide (FMN)/flavin adenine dinucleotide (FAD), respectively. In …

Aptamers are single-stranded nucleic acid molecules that possess properties comparable to
those of protein monoclonal antibodies, and thus are clear alternatives to long established …