Dabigatran, rivaroxaban, apixaban, edoxaban, and betrixaban are direct oral anticoagulants
(DOACs). Their inter-individual variability in pharmacodynamics and pharmacokinetics …

ATP-binding cassette transporter B1 (ABCB1; P-glycoprotein; multidrug resistance protein 1)
is an adenosine triphosphate (ATP)-dependent efflux transporter located in the plasma …

Background Pharmacogenetic determinants of the response of patients to clopidogrel
contribute to variability in the biologic antiplatelet activity of the drug. The effect of these …

ABCB1 (MDR1) is one of many ubiquitous adenosine triphosphate (ATP)-binding cassette
(ABC) genes present in all kingdoms of life that is responsible for cellular homeostasis [1–3] …

Drug transporters are increasingly recognized to be important to drug disposition and
response. P‐glycoprotein, the encoded product of the human MDR1 (ABCB1) gene, is of …

1. P-glycoprotein (P-gp/MDR1), one of the most clinically important transmembrane
transporters in humans, is encoded by the ABCB1/MDR1 gene. Recent insights into the …

Recent progress in understanding the molecular mechanisms of bile formation and
cholestasis have led to new insights into the pathogenesis of drug‐induced cholestasis. This …

The calcineurin inhibitors ciclosporin (cyclosporine) and tacrolimus are immunosuppressant
drugs used for the prevention of organ rejection following transplantation. Both agents are …

P-glycoprotein is the product of the ABCB1 [also known as multidrug resistance 1 (MDR1)]
gene. It translocates a broad variety of xenobiotics out of cells. P-glycoprotein was first …

Ethnicity is one factor that may account for the observed differences in both
pharmacokinetics (PK) and pharmacodynamics (PD) of drugs, resulting in variability in …