Regulating the human HECT E3 ligases
J Sluimer, B Distel - Cellular and molecular life sciences, 2018 - Springer
Ubiquitination, the covalent attachment of ubiquitin to proteins, by E3 ligases of the HECT
(homologous to E6AP C terminus) family is critical in controlling diverse physiological …
(homologous to E6AP C terminus) family is critical in controlling diverse physiological …
[HTML][HTML] The functions and regulation of Smurfs in cancers
L Fu, CP Cui, X Zhang, L Zhang - Seminars in cancer biology, 2020 - Elsevier
Smad ubiquitination regulatory factor 1 (Smurf1) and Smurf2 are HECT-type E3 ubiquitin
ligases, and both Smurfs were initially identified to regulate Smad protein stability in the TGF …
ligases, and both Smurfs were initially identified to regulate Smad protein stability in the TGF …
SSDraw: software for generating comparative protein secondary structure diagrams
The program SSDraw generates publication‐quality protein secondary structure diagrams
from three‐dimensional protein structures. To depict relationships between secondary …
from three‐dimensional protein structures. To depict relationships between secondary …
Using ubiquitin binders to decipher the ubiquitin code
Post-translational modifications (PTMs) by ubiquitin (Ub) are versatile, highly dynamic, and
involved in nearly all aspects of eukaryote biological function. The reversibility and …
involved in nearly all aspects of eukaryote biological function. The reversibility and …
RNF111-facilitated neddylation potentiates cGAS-mediated antiviral innate immune response
The cytosolic DNA sensor cyclic GMP-AMP (cGAMP) synthetase (cGAS) has emerged as a
fundamental component fueling the anti-pathogen immunity. Because of its pivotal role in …
fundamental component fueling the anti-pathogen immunity. Because of its pivotal role in …
Adaptors as the regulators of HECT ubiquitin ligases
The HECT (homologous to E6AP C-terminus) ubiquitin ligases (E3s) are a small family of
highly conserved enzymes involved in diverse cellular functions and pathological …
highly conserved enzymes involved in diverse cellular functions and pathological …
The post-translational modifications of Smurf2 in TGF-β signaling
Y Bai, Y Ying - Frontiers in molecular biosciences, 2020 - frontiersin.org
Smad ubiquitin regulatory factor 2 (Smurf2), an essential negative regulator of TGF-β
signaling, ubiquitinates TGF-β receptors (TβRs) and Smad proteins, inducing their …
signaling, ubiquitinates TGF-β receptors (TβRs) and Smad proteins, inducing their …
TTC3 contributes to TGF-β1-induced epithelial−mesenchymal transition and myofibroblast differentiation, potentially through SMURF2 ubiquitylation and degradation
JH Kim, S Ham, Y Lee, GY Suh, YS Lee - Cell Death & Disease, 2019 - nature.com
Transforming growth factor-β (TGF-β) acts as a key cytokine in epithelial− mesenchymal
transition (EMT) and myofibroblast differentiation, which are important for normal tissue …
transition (EMT) and myofibroblast differentiation, which are important for normal tissue …
Regulation of ubiquitin enzymes in the TGF-β pathway
PV Iyengar - International journal of molecular sciences, 2017 - mdpi.com
The transforming growth factor-β (TGF-β) pathway has a tumor suppressor role in normal
and premalignant cells but promotes oncogenesis in advanced cancer cells. Components of …
and premalignant cells but promotes oncogenesis in advanced cancer cells. Components of …
Neddylation modification of the U3 snoRNA-binding protein RRP9 by Smurf1 promotes tumorigenesis
M Du, F Liu, Y Chang, S Tong, W Liu, Y Chen… - Journal of Biological …, 2021 - ASBMB
Neddylation is a posttranslational modification that attaches ubiquitin-like protein Nedd8 to
protein targets via Nedd8-specific E1-E2-E3 enzymes and modulates many important …
protein targets via Nedd8-specific E1-E2-E3 enzymes and modulates many important …