Pancreatic β-cell electrical activity and insulin secretion: of mice and men

P Rorsman, FM Ashcroft - Physiological reviews, 2018 - journals.physiology.org
The pancreatic β-cell plays a key role in glucose homeostasis by secreting insulin, the only
hormone capable of lowering the blood glucose concentration. Impaired insulin secretion …

Interplay between miRNAs and human diseases

P Paul, A Chakraborty, D Sarkar… - Journal of cellular …, 2018 - Wiley Online Library
MicroRNAs (miRNAs) are endogenous, non‐coding RNAs, which have evoked a great deal
of interest due to their importance in many aspects of homeostasis and diseases …

Obesity in type 1 diabetes: pathophysiology, clinical impact, and mechanisms

KD Corbin, KA Driscoll, RE Pratley, SR Smith… - Endocrine …, 2018 - academic.oup.com
There has been an alarming increase in the prevalence of obesity in people with type 1
diabetes in recent years. Although obesity has long been recognized as a major risk factor …

MicroRNAs in metabolism and metabolic disorders

V Rottiers, AM Näär - Nature reviews Molecular cell biology, 2012 - nature.com
MicroRNAs (miRNAs) have recently emerged as key regulators of metabolism. For example,
miR-33a and miR-33b have a crucial role in controlling cholesterol and lipid metabolism in …

Significance of serum microRNAs in pre-diabetes and newly diagnosed type 2 diabetes: a clinical study

L Kong, J Zhu, W Han, X Jiang, M Xu, Y Zhao, Q Dong… - Acta …, 2011 - Springer
To explore the clinical significance of seven diabetes-related serum microRNAs (miR-9, miR-
29a, miR-30d, miR34a, miR-124a, miR146a and miR375) during the pathogenesis of type 2 …

MicroRNA 144 impairs insulin signaling by inhibiting the expression of insulin receptor substrate 1 in type 2 diabetes mellitus

DS Karolina, A Armugam, S Tavintharan, MTK Wong… - PloS one, 2011 - journals.plos.org
Background Dysregulation of microRNA (miRNA) expression in various tissues and body
fluids has been demonstrated to be associated with several diseases, including Type 2 …

Influence of miRNA in insulin signaling pathway and insulin resistance: micro‐molecules with a major role in type‐2 diabetes

C Chakraborty, CGP Doss… - Wiley …, 2014 - Wiley Online Library
The prevalence of type‐2 diabetes (T2D) is increasing significantly throughout the globe
since the last decade. This heterogeneous and multifactorial disease, also known as insulin …

Identification of forensically relevant body fluids using a panel of differentially expressed microRNAs

EK Hanson, H Lubenow, J Ballantyne - Analytical biochemistry, 2009 - Elsevier
The serology-based methods routinely used in forensic casework for the identification of
biological fluids are costly in terms of time and sample and have varying degrees of …

Diabetes mellitus, a microRNA-related disease?

C Guay, E Roggli, V Nesca, C Jacovetti… - Translational Research, 2011 - Elsevier
Diabetes mellitus is a complex disease resulting in altered glucose homeostasis. In both
type 1 and type 2 diabetes mellitus, pancreatic β cells cannot secrete appropriate amounts …

Circular RNA circGlis3 protects against islet β-cell dysfunction and apoptosis in obesity

Y Liu, Y Yang, C Xu, J Liu, J Chen, G Li… - Nature …, 2023 - nature.com
Pancreatic β-cell compensation is a major mechanism in delaying T2DM progression. Here
we report the abnormal high expression of circGlis3 in islets of male mice with obesity and …