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Pancreatic β-cell electrical activity and insulin secretion: of mice and men
P Rorsman, FM Ashcroft - Physiological reviews, 2018 - journals.physiology.org
The pancreatic β-cell plays a key role in glucose homeostasis by secreting insulin, the only
hormone capable of lowering the blood glucose concentration. Impaired insulin secretion …
hormone capable of lowering the blood glucose concentration. Impaired insulin secretion …
Interplay between miRNAs and human diseases
P Paul, A Chakraborty, D Sarkar… - Journal of cellular …, 2018 - Wiley Online Library
MicroRNAs (miRNAs) are endogenous, non‐coding RNAs, which have evoked a great deal
of interest due to their importance in many aspects of homeostasis and diseases …
of interest due to their importance in many aspects of homeostasis and diseases …
Obesity in type 1 diabetes: pathophysiology, clinical impact, and mechanisms
There has been an alarming increase in the prevalence of obesity in people with type 1
diabetes in recent years. Although obesity has long been recognized as a major risk factor …
diabetes in recent years. Although obesity has long been recognized as a major risk factor …
MicroRNAs in metabolism and metabolic disorders
V Rottiers, AM Näär - Nature reviews Molecular cell biology, 2012 - nature.com
MicroRNAs (miRNAs) have recently emerged as key regulators of metabolism. For example,
miR-33a and miR-33b have a crucial role in controlling cholesterol and lipid metabolism in …
miR-33a and miR-33b have a crucial role in controlling cholesterol and lipid metabolism in …
Significance of serum microRNAs in pre-diabetes and newly diagnosed type 2 diabetes: a clinical study
L Kong, J Zhu, W Han, X Jiang, M Xu, Y Zhao, Q Dong… - Acta …, 2011 - Springer
To explore the clinical significance of seven diabetes-related serum microRNAs (miR-9, miR-
29a, miR-30d, miR34a, miR-124a, miR146a and miR375) during the pathogenesis of type 2 …
29a, miR-30d, miR34a, miR-124a, miR146a and miR375) during the pathogenesis of type 2 …
MicroRNA 144 impairs insulin signaling by inhibiting the expression of insulin receptor substrate 1 in type 2 diabetes mellitus
DS Karolina, A Armugam, S Tavintharan, MTK Wong… - PloS one, 2011 - journals.plos.org
Background Dysregulation of microRNA (miRNA) expression in various tissues and body
fluids has been demonstrated to be associated with several diseases, including Type 2 …
fluids has been demonstrated to be associated with several diseases, including Type 2 …
Influence of miRNA in insulin signaling pathway and insulin resistance: micro‐molecules with a major role in type‐2 diabetes
C Chakraborty, CGP Doss… - Wiley …, 2014 - Wiley Online Library
The prevalence of type‐2 diabetes (T2D) is increasing significantly throughout the globe
since the last decade. This heterogeneous and multifactorial disease, also known as insulin …
since the last decade. This heterogeneous and multifactorial disease, also known as insulin …
Identification of forensically relevant body fluids using a panel of differentially expressed microRNAs
EK Hanson, H Lubenow, J Ballantyne - Analytical biochemistry, 2009 - Elsevier
The serology-based methods routinely used in forensic casework for the identification of
biological fluids are costly in terms of time and sample and have varying degrees of …
biological fluids are costly in terms of time and sample and have varying degrees of …
Diabetes mellitus, a microRNA-related disease?
C Guay, E Roggli, V Nesca, C Jacovetti… - Translational Research, 2011 - Elsevier
Diabetes mellitus is a complex disease resulting in altered glucose homeostasis. In both
type 1 and type 2 diabetes mellitus, pancreatic β cells cannot secrete appropriate amounts …
type 1 and type 2 diabetes mellitus, pancreatic β cells cannot secrete appropriate amounts …
Circular RNA circGlis3 protects against islet β-cell dysfunction and apoptosis in obesity
Y Liu, Y Yang, C Xu, J Liu, J Chen, G Li… - Nature …, 2023 - nature.com
Pancreatic β-cell compensation is a major mechanism in delaying T2DM progression. Here
we report the abnormal high expression of circGlis3 in islets of male mice with obesity and …
we report the abnormal high expression of circGlis3 in islets of male mice with obesity and …