A major challenge in current biology is to understand the genetic basis of variation for
quantitative traits. We review the principles of quantitative trait locus map** and …

▪ Abstract Phenotypic variation for quantitative traits results from the segregation of alleles at
multiple quantitative trait loci (QTL) with effects that are sensitive to the genetic, sexual, and …

We know very little about the genetic basis of adaptation. Indeed, we can make no
theoretical predictions, however heuristic, about the distribution of phenotypic effects among …

A paradigm of evolutionary biology is that adaptation and reproductive isolation are caused
by a nearly infinite number of mutations of individually small effect. Here, we test this …

Most genetic research has used inbred organisms and has not explored the complexity of
natural genetic variation present in outbred populations. The translation of genotype to …

Intralocus sexual conflict occurs when selection on a shared trait in one sex displaces the
other sex from its phenotypic optimum. It arises because many shared traits have a common …

This article reviews the principle of minimum description length (MDL) for problems of model
selection. By viewing statistical modeling as a means of generating descriptions of observed …

Until recently, it was impracticable to identify the genes that are responsible for variation in
continuous traits, or to directly observe the effects of their different alleles. Now, the …

A central challenge in evolutionary biology is to identify genes underlying ecologically
important traits and describe the fitness consequences of naturally occurring variation at …

Ever since the integration of Mendelian genetics into evolutionary biology in the early 20th
century, evolutionary geneticists have for the most part treated genes and mutations as …