Type 1 and type 2 diabetes mellitus (DM) are chronic diseases that affect nearly 425 million
people worldwide, leading to poor health outcomes and high health care costs. High …

A growing body of evidence suggests that oxidative stress plays a key role in the
pathogenesis of micro-and macrovascular diabetic complications. The increased oxidative …

What is already known about this subject Circulating concentrations of branched‐chain
amino acids (BCAAs) can affect carbohydrate metabolism in skeletal muscle, and therefore …

In this fast-food era, people depend on ready-made foods and engage in minimal physical
activities that ultimately change their food habits. Majorities of such foods have harmful …

In the nervous system, NMDA receptors (NMDARs) participate in neurotransmission and
modulate the viability of neurons. In contrast, little is known about the role of NMDARs in …

Iron is an essential element involved in a variety of physiological functions. In the pancreatic
beta-cells, being part of Fe-S cluster proteins, it is necessary for the correct insulin synthesis …

Background Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have been
suggested to prevent the development of metabolic disorders. However, their individual role …

Glutamate represents a key excitatory neurotransmitter in the central nervous system, and
also modulates the function and viability of endocrine cells in pancreatic islets. In insulin …

Substantial epidemiological evidence indicates that a diet rich in polyphenols protects
against develo** type 2 diabetes. The phenylethanoid glycoside verbascoside/acteoside …

Aims/hypothesis Metabolomic profiling in populations with impaired glucose tolerance has
revealed that branched chain and aromatic amino acids (BCAAs) are predictive of type 2 …