Developmental mechanisms underlying the evolution of human cortical circuits

P Vanderhaeghen, F Polleux - Nature Reviews Neuroscience, 2023 - nature.com
The brain of modern humans has evolved remarkable computational abilities that enable
higher cognitive functions. These capacities are tightly linked to an increase in the size and …

[HTML][HTML] Evolution of cortical neurons supporting human cognition

AA Galakhova, S Hunt, R Wilbers, DB Heyer… - Trends in cognitive …, 2022 - cell.com
Human cognitive abilities are generally thought to arise from cortical expansion over the
course of human brain evolution. In addition to increased neuron numbers, this cortical …

Connectomic comparison of mouse and human cortex

S Loomba, J Straehle, V Gangadharan, N Heike… - Science, 2022 - science.org
The human cerebral cortex houses 1000 times more neurons than that of the cerebral cortex
of a mouse, but the possible differences in synaptic circuits between these species are still …

Comparative transcriptomics reveals human-specific cortical features

NL Jorstad, JHT Song, D Exposito-Alonso, H Suresh… - Science, 2023 - science.org
The cognitive abilities of humans are distinctive among primates, but their molecular and
cellular substrates are poorly understood. We used comparative single-nucleus …

Functional connectomics spanning multiple areas of mouse visual cortex

MICrONS Consortium, JA Bae, M Baptiste, CA Bishop… - BioRxiv, 2021 - biorxiv.org
To understand the brain we must relate neurons' functional responses to the circuit
architecture that shapes them. Here, we present a large functional connectomics dataset …

A molecular and cellular perspective on human brain evolution and tempo

FW Lindhout, FM Krienen, KS Pollard, MA Lancaster - Nature, 2024 - nature.com
The evolution of the modern human brain was accompanied by distinct molecular and
cellular specializations, which underpin our diverse cognitive abilities but also increase our …

Allometric rules for mammalian cortical layer 5 neuron biophysics

L Beaulieu-Laroche, NJ Brown, M Hansen, EHS Toloza… - Nature, 2021 - nature.com
The biophysical properties of neurons are the foundation for computation in the brain.
Neuronal size is a key determinant of single neuron input–output features and varies …

[HTML][HTML] Enhanced dendritic compartmentalization in human cortical neurons

L Beaulieu-Laroche, EHS Toloza, MS Van der Goes… - Cell, 2018 - cell.com
The biophysical features of neurons shape information processing in the brain. Cortical
neurons are larger in humans than in other species, but it is unclear how their size affects …

Map** human cortical areas in vivo based on myelin content as revealed by T1-and T2-weighted MRI

MF Glasser, DC Van Essen - Journal of neuroscience, 2011 - jneurosci.org
Noninvasively map** the layout of cortical areas in humans is a continuing challenge for
neuroscience. We present a new method of map** cortical areas based on myelin content …

General cortical and special prefrontal connections: principles from structure to function

H Barbas - Annual review of neuroscience, 2015 - annualreviews.org
How is the vast brain communication system organized? A structural model relates
connections to laminar differences between linked areas. The model is based on the …