Chronic psychosocial stress is increasingly recognized as a risk factor for late-onset
Alzheimer's disease (LOAD) and associated cognitive deficits. Chronic stress also primes …

Abstract Disrupted-in-Schizophrenia 1 (DISC1) is a gene known as a risk factor for mental
illnesses possibly associated with dopamine impairments. DISC1 is a scaffold protein …

Neurons depend on mitochondrial functions for membrane excitability, neurotransmission,
and plasticity. Mitochondrial dynamics are important for neural cell maintenance. To …

Mitochondrial dysfunction is an early feature of Alzheimer's disease (AD). Accumulated
damaged mitochondria, which are associated with impaired mitophagy, contribute to …

Maintenance of synaptic homeostasis is a challenging task, due to the intricate spatial
organization and intense activity of synapses. Typically, synapses are located far away from …

Synapses are complex structures that allow communication between neurons in the central
nervous system. Studies conducted in vertebrate and invertebrate models have contributed …

Chronic mental illnesses (CMI), such as schizophrenia or recurrent affective disorders, are
complex conditions with both genetic and non-genetic elements. In many other chronic brain …

Abstract Disrupted in schizophrenia 1 (DISC1) is an important hub protein, forming
multimeric complexes by self‐association and interacting with a large number of synaptic …

In genetically complex diseases, the search for missing heritability is focusing on rare
variants with large effect. Thanks to next generation sequencing technologies, genome-wide …

Since the middle of the past century, we have serendipitously come across treatment
regimens that can partially ameliorate psychosis and depression. Nonetheless, the …