Objectives Idiopathic pulmonary fibrosis (IPF) is a chronic fibrotic lung disease characterized
by dry cough, fatigue, and progressive exertional dyspnea. Lung parenchyma and …

Idiopathic pulmonary fibrosis is a progressive lung disease of unknown etiology
characterized by distorted distal lung architecture, inflammation, and fibrosis. Several lung …

Background Mortality risk assessment in interstitial lung disease (ILD) is challenging. Our
objective was to determine the prognostic significance of BMI and change in weight in the …

Idiopathic pulmonary fibrosis (IPF) is a progressive disease with significant mortality and
morbidity. Approval of antifibrotic therapy has ameliorated disease progression, but therapy …

Lipids are major actors and regulators of physiological processes within the lung. Initial
research has described their critical role in tissue homeostasis and in orchestrating cellular …

Pulmonary fibrosis (PF) can be idiopathic or driven by a specific insult, genetic susceptibility,
or disease process. Inflammation plays a role in the pathophysiology, the extent of which …

Background The circulating metabolome, reflecting underlying cellular processes and
disease biology, has not been fully characterized in patients with idiopathic pulmonary …

Idiopathic pulmonary fibrosis (IPF) is a progressive disease with significant mortality.
Prognostic biomarkers to identify rapid progressors are urgently needed to improve patient …

Exposure to ozone causes decrements in pulmonary function, a response associated with
alterations in lung lipids. Pulmonary lipid homeostasis is dependent on the activity of …

Many inhalation exposures induce pulmonary inflammation contributing to disease
progression. Inflammatory processes are actively regulated via mediators including …