A survey of protein databases indicates that the majority of enzymes exist in oligomeric
forms, with about half of those found in the UniProt database being homodimeric …

Highlights•Sparsely populated protein states can play significant biological roles.•NMR
spectroscopy can structurally and dynamically characterize 'invisible'protein states.•We …

Sampling and genomic efforts over the past decade have revealed an enormous quantity
and diversity of life in Earth's extreme environments. This new knowledge of life on Earth …

Pressure is a key variable in the phase behavior of responsive polymers, both for
applications and from a fundamental point of view. In this feature article, we review recent …

Protein function hinges on small shifts of three-dimensional structure. Elevating temperature
or pressure may provide experimentally accessible insights into such shifts, but the effects of …

Compared to soluble protein counterparts, the understanding of membrane protein stability,
solvent interactions, and function are not as well understood. Recent advancements in …

Cell membranes represent a complex and variable medium in time and space of lipids and
proteins. Their physico-chemical properties are determined by lipid components which can …

Pressure is a fundamental thermodynamic parameter controlling the behavior of biological
macromolecules. Pressure affects protein denaturation, kinetic parameters of enzymes …

Intrinsic thermodynamic fluctuations within biomolecules are crucial for their function, and
flexibility is one of the strategies that evolution has developed to adapt to extreme …

The adenosine di-phosphate (ADP) ribosylation factor (Arf) small guanosine tri-phosphate
(GTP) ases function as molecular switches to activate signaling cascades that control …