Between the 1960s and 1980s, most life scientists focused their attention on studies of
nucleic acids and the translation of the coded information. Protein degradation was a …

Cullin–RING complexes comprise the largest known class of ubiquitin ligases. Owing to the
great diversity of their substrate-receptor subunits, it is possible that there are hundreds of …

Lysine methylation of histones in vivo occurs in three states: mono-, di-and tri-methyl.
Histone H3 has been found to be di-methylated at lysine 4 (K4) in active euchromatic …

Cullin-RING ubiquitin ligases (CRLs) are dynamic modular platforms that regulate myriad
biological processes through target-specific ubiquitylation. Our knowledge of this system …

The plant hormone auxin is central in many aspects of plant development. Previous studies
have implicated the ubiquitin-ligase SCFTIR1 and the AUX/IAA proteins in auxin response …

Plants, like other eukaryotes, rely on proteolysis to control the abundance of key regulatory
proteins and enzymes. Strikingly, genome-wide studies have revealed that the ubiquitin-26S …

The 26 S proteasome mediates degradation of ubiquitin-conjugated proteins. Although
ubiquitin is recycled from proteasome substrates, the molecular basis of deubiquitination at …

Attachment of ubiquitin to proteins is a crucial step in many cellular regulatory mechanisms
and contributes to numerous biological processes, including embryonic development, the …

Many disease resistance (R) proteins of plants detect the presence of disease-causing
bacteria, viruses, or fungi by recognizing specific pathogen effector molecules that are …

Bark protects the tree against environmental insults. Here, we analyzed whether this
defensive strategy could be utilized to broadly enhance protection against colitis. As a proof …