Most bacteria are surrounded by a peptidoglycan cell wall that defines their shape and
protects them from osmotic lysis. The expansion and division of this structure therefore plays …

Tuberculosis (TB), caused by the intracellular pathogen Mycobacterium tuberculosis,
remains one of the leading causes of mortality across the world. There is an urgent …

The peptidoglycan cell wall is essential for the survival and morphogenesis of bacteria. For
decades, it was thought that only class A penicillin-binding proteins (PBPs) and related …

The peptidoglycan (PG) cell wall is an extra-cytoplasmic glycopeptide polymeric structure
that protects bacteria from osmotic lysis and determines cellular shape. Since the cell wall …

Mycobacterium tuberculosis (Mtb), the etiological agent of tuberculosis (TB), is recognized
as a global health emergency as promoted by the World Health Organization. Over 1 million …

Cell division in Escherichia coli is mediated by a large protein complex called the divisome.
Most of the divisome proteins have been identified, but how they assemble onto the Z ring …

The lytic transglycosylases (LTs) are bacterial enzymes that catalyze the non-hydrolytic
cleavage of the peptidoglycan structures of the bacterial cell wall. They are not catalysts of …

Peptidoglycan (PG) is an essential component in the cell wall of nearly all bacteria, forming
a continuous, mesh-like structure, called the sacculus, around the cytoplasmic membrane to …

To maintain cellular structure and integrity during division, Gram-negative bacteria must
carefully coordinate constriction of a tripartite cell envelope of inner membrane …

Membrane lipids diffuse rapidly in the plane of the membrane but their ability to flip
spontaneously across a membrane bilayer is hampered by a significant energy barrier. Thus …