Chemotherapy is a critical treatment for endocrine-related cancers; however,
chemoresistance and disease recurrence remain a challenge. The interplay between cancer …

Breast cancer is one of the leading deaths in all kinds of malignancies; therefore, it is
important for early detection. At the primary tumor site, tumor cells could take on …

Background Pancreatic cancer (PC) is among the most lethal cancers. The lack of effective
tools for early detection results in late tumor detection and, consequently, high mortality rate …

Oxysterols, oxidized derivatives of cholesterol, have been implicated in multiple pathologies,
including cancer. In breast cancer, the link is especially strong due to interactions between …

Pancreatic ductal adenocarcinoma (PDAC) accounts for about 90% of all pancreatic cancer
cases. Five-year survival rates have remained below 12% since the 1970s, in part due to the …

The complexity of lung adenocarcinoma (LUAD), the development of which involves many
interacting biological processes, makes it difficult to find therapeutic biomarkers for …

Pancreatic ductal adenocarcinoma (PDAC) is one of malignancies with worst outcomes
among digestive system tumors. Identification of novel biomarkers is of great significance for …

Background Type 2 diabetes mellitus (T2DM) is a chronic endocrine metabolic disease
caused by insulin dysregulation. Studies have shown that aging-related oxidative stress (as …

The period (PER) and cryptochrome (CRY) families play critical roles in circadian rhythms.
The imbalance of circadian factors may lead to the occurrence of cancer. Expressions of …

Background Many members of the oxysterol-binding protein-related protein (ORP) family
have been characterized in detail over the past decades, but the lipid transport and other …