Anti‐inflammatory, antioxidant, and immunomodulatory effects of Berberis vulgaris and its constituent berberine, experimental and clinical, a review

F Shakeri, S Kiani, G Rahimi… - Phytotherapy …, 2024 - Wiley Online Library
Berberis vulgaris (B. vulgaris or barberry) is a medicinal plant that has been used for various
purposes in traditional medicine. Berberine is one of the main alkaloids isolated from B …

Applications and advancements of nanoparticle-based drug delivery in alleviating lung cancer and chronic obstructive pulmonary disease

G De Rubis, KR Paudel, L Corrie, S Mehndiratta… - Naunyn-Schmiedeberg's …, 2024 - Springer
Lung cancer (LC) and chronic obstructive pulmonary disease (COPD) are among the
leading causes of mortality worldwide. Cigarette smoking is among the main aetiologic …

Emerging role of tumor suppressing microRNAs as therapeutics in managing non-small cell lung cancer

S Singh, S Saxena, H Sharma, KR Paudel… - … -Research and Practice, 2024 - Elsevier
Lung cancer (LC) is the second leading cause of death across the globe after breast cancer.
There are two types of LC viz. small cell lung cancer (SCLC) and non-small cell lung cancer …

18-β-Glycyrrhetinic acid encapsulated PLGA nanoparticles attenuate lung cancer proliferation and migration

KR Paudel, MSB Mohamad, G De Rubis… - Journal of Drug Delivery …, 2024 - Elsevier
Conventional treatment methods to treat lung cancer include radiation therapy,
chemotherapy, and immunotherapy. However, they cause severe adverse effects and …

Natural product/diet-based regulation of macrophage polarization: Implications in treatment of inflammatory-related diseases and cancer

M Ashrafizadeh, AR Aref, G Sethi, YN Ertas… - The Journal of Nutritional …, 2024 - Elsevier
Macrophages are phagocytic cells with important physiological functions, including the
digestion of cellular debris, foreign substances, and microbes, as well as tissue …

Zerumbone-incorporated liquid crystalline nanoparticles inhibit proliferation and migration of non-small-cell lung cancer in vitro

B Manandhar, KR Paudel, DD Clarence… - Naunyn-Schmiedeberg's …, 2024 - Springer
Lung cancer is the second most prevalent type of cancer and is responsible for the highest
number of cancer-related deaths worldwide. Non-small-cell lung cancer (NSCLC) makes up …

Berberine-loaded engineered nanoparticles attenuate TGF-β-induced remodelling in human bronchial epithelial cells

G De Rubis, KR Paudel, G Liu, V Agarwal… - Toxicology in Vitro, 2023 - Elsevier
Airway remodelling occurs in chronic respiratory diseases (CRDs) such as asthma and
chronic obstructive pulmonary disease (COPD). It is characterized by aberrant activation of …

Dissecting the in vitro fate of plant-derived bioactive encapsulated nanoparticles in lung diseases

AB Saeid, VK Patel, S Mehndiratta, R Rajput… - Food Bioscience, 2023 - Elsevier
Lung diseases such as asthma, chronic obstructive pulmonary disease (COPD), and lung
cancer are prevalent worldwide, with high mortality rates. There are many pathways …

Phytochemical-mediated efferocytosis and autophagy in inflammation control

A Vafadar, A Tajbakhsh… - Cell Death …, 2024 - nature.com
Efferocytosis, the clearance of apoptotic cells, is a critical process that maintains tissue
homeostasis and immune regulation. Defective efferocytosis is linked to the development of …

Agarwood oil nanoemulsion counteracts LPS-induced inflammation and oxidative stress in RAW264. 7 mouse macrophages

R Malik, KR Paudel, B Manandhar, G De Rubis… - … -Research and Practice, 2023 - Elsevier
Purpose Oxidative stress and inflammation are key pathophysiological features of chronic
respiratory diseases, including asthma and chronic obstructive pulmonary disease (COPD) …