Ion channel voltage sensors: structure, function, and pathophysiology

WA Catterall - Neuron, 2010 - cell.com
Voltage-gated ion channels generate electrical signals in species from bacteria to man.
Their voltage-sensing modules are responsible for initiation of action potentials and graded …

Structure of potassium channels

Q Kuang, P Purhonen, H Hebert - Cellular and molecular life sciences, 2015 - Springer
Potassium channels ubiquitously exist in nearly all kingdoms of life and perform diverse but
important functions. Since the first atomic structure of a prokaryotic potassium channel …

Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment

SB Long, X Tao, EB Campbell, R MacKinnon - Nature, 2007 - nature.com
Abstract Voltage-dependent K+ (Kv) channels repolarize the action potential in neurons and
muscle. This type of channel is gated directly by membrane voltage through protein domains …

[BOOK][B] The structure of biological membranes

PL Yeagle - 2004 - taylorfrancis.com
Recent research has provided an abundance of new information on membrane
biochemistry. Now more than ever, it is essential to update our current understanding of …

Phospholipids and the origin of cationic gating charges in voltage sensors

D Schmidt, QX Jiang, R MacKinnon - Nature, 2006 - nature.com
Cells communicate with their external environment through physical and chemical
processes that take place in the cell-surrounding membrane. The membrane serves as a …

Voltage-gated potassium channels: a structural examination of selectivity and gating

DM Kim, CM Nimigean - Cold Spring Harbor …, 2016 - cshperspectives.cshlp.org
Voltage-gated potassium channels play a fundamental role in the generation and
propagation of the action potential. The discovery of these channels began with predictions …

Modeling and simulation of ion channels

C Maffeo, S Bhattacharya, J Yoo, D Wells… - Chemical …, 2012 - ACS Publications
Transport of ions through pores in membranes is a process of fundamental importance to
cell biology. In living organisms, such transport is facilitated by ion channels that utilize the …

How does voltage open an ion channel?

F Tombola, MM Pathak, EY Isacoff - Annu. Rev. Cell Dev. Biol., 2006 - annualreviews.org
Neurons transmit information through electrical signals generated by voltage-gated ion
channels. These channels consist of a large superfamily of proteins that form channels …

High-yield production of “difficult-to-express” proteins in a continuous exchange cell-free system based on CHO cell lysates

L Thoring, SK Dondapati, M Stech, DA Wüstenhagen… - Scientific reports, 2017 - nature.com
Cell-free protein synthesis (CFPS) represents a promising technology for efficient protein
production targeting especially so called “difficult-to-express” proteins whose synthesis is …

An inward-facing conformation of a putative metal-chelate-type ABC transporter

HW Pinkett, AT Lee, P Lum, KP Locher, DC Rees - Science, 2007 - science.org
The crystal structure of a putative metal-chelate–type adenosine triphosphate (ATP)–binding
cassette (ABC) transporter encoded by genes HI1470 and HI1471 of Haemophilus …