An update on drugs with therapeutic potential for SARS-CoV-2 (COVID-19) treatment

S Drożdżal, J Rosik, K Lechowicz, F Machaj… - Drug Resistance …, 2021 - Elsevier
The COVID-19 pandemic is one of the greatest threats to human health in the 21st century
with more than 257 million cases and over 5.17 million deaths reported worldwide (as of …

COVID-19: a review on the novel coronavirus disease evolution, transmission, detection, control and prevention

A Sharma, I Ahmad Farouk, SK Lal - Viruses, 2021 - mdpi.com
Three major outbreaks of the coronavirus, a zoonotic virus known to cause respiratory
disease, have been reported since 2002, including SARS-CoV, MERS-CoV and the most …

Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2

L Swadling, MO Diniz, NM Schmidt, OE Amin… - Nature, 2022 - nature.com
Individuals with potential exposure to severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) do not necessarily develop PCR or antibody positivity, suggesting that some …

Molecular mechanism of interaction between SARS-CoV-2 and host cells and interventional therapy

Q Zhang, R **ang, S Huo, Y Zhou, S Jiang… - Signal transduction and …, 2021 - nature.com
The pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) infection has resulted in an unprecedented setback …

SARS-CoV-2 accessory proteins in viral pathogenesis: knowns and unknowns

N Redondo, S Zaldívar-López, JJ Garrido… - Frontiers in …, 2021 - frontiersin.org
There are still many unanswered questions concerning viral SARS-CoV-2 pathogenesis in
COVID-19. Accessory proteins in SARS-CoV-2 consist of eleven viral proteins whose roles …

[HTML][HTML] Coronavirus biology and replication: implications for SARS-CoV-2

P V'kovski, A Kratzel, S Steiner, H Stalder… - Nature Reviews …, 2021 - nature.com
The SARS-CoV-2 pandemic and its unprecedented global societal and economic disruptive
impact has marked the third zoonotic introduction of a highly pathogenic coronavirus into the …

Mechanisms of SARS-CoV-2 transmission and pathogenesis

AG Harrison, T Lin, P Wang - Trends in immunology, 2020 - cell.com
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) marks
the third highly pathogenic coronavirus to spill over into the human population. SARS-CoV-2 …

The SARS-CoV-2 nucleocapsid protein: its role in the viral life cycle, structure and functions, and use as a potential target in the development of vaccines and …

W Wu, Y Cheng, H Zhou, C Sun, S Zhang - Virology journal, 2023 - Springer
Abstract Coronavirus disease 2019 (COVID-19) continues to take a heavy toll on personal
health, healthcare systems, and economies around the globe. Scientists are expending …

Detection technologies and recent developments in the diagnosis of COVID-19 infection

P Rai, BK Kumar, VK Deekshit, I Karunasagar… - Applied microbiology …, 2021 - Springer
COVID-19 is a disease caused by SARS-CoV-2 capable of causing mild to severe infections
in humans. Since its first appearance in China in December 2019, the pandemic has spread …

Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19

Y Peng, AJ Mentzer, G Liu, X Yao, Z Yin, D Dong… - Nature …, 2020 - nature.com
The development of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
vaccines and therapeutics will depend on understanding viral immunity. We studied T cell …