High-resolution native mass spectrometry
Native mass spectrometry (MS) involves the analysis and characterization of
macromolecules, predominantly intact proteins and protein complexes, whereby as much as …
macromolecules, predominantly intact proteins and protein complexes, whereby as much as …
Ultraviolet photodissociation mass spectrometry for analysis of biological molecules
The development of new ion-activation/dissociation methods continues to be one of the most
active areas of mass spectrometry owing to the broad applications of tandem mass …
active areas of mass spectrometry owing to the broad applications of tandem mass …
Protein–small molecule interactions in native mass spectrometry
Small molecule drug discovery has been propelled by the continual development of novel
scientific methodologies to occasion therapeutic advances. Although established …
scientific methodologies to occasion therapeutic advances. Although established …
An integrated native mass spectrometry and top-down proteomics method that connects sequence to structure and function of macromolecular complexes
Mass spectrometry (MS) has become a crucial technique for the analysis of protein
complexes. Native MS has traditionally examined protein subunit arrangements, while …
complexes. Native MS has traditionally examined protein subunit arrangements, while …
Top-down proteomics: ready for prime time?
Beyond the genetic code, the human proteome is greatly diversified by genetic variations,
alternative splicing of RNA transcripts, and post-translational modifications (PTMs). 6, 7 In …
alternative splicing of RNA transcripts, and post-translational modifications (PTMs). 6, 7 In …
Ion activation methods for peptides and proteins
JS Brodbelt - Analytical chemistry, 2016 - ACS Publications
The analysis of peptides and proteins as well as the grander scope of proteomics (large
scale study of proteins) has been advanced by the development of a versatile array of ion …
scale study of proteins) has been advanced by the development of a versatile array of ion …
Top or middle? Up or down? Toward a standard lexicon for protein top-down and allied mass spectrometry approaches
In recent years, there has been increasing interest in top-down mass spectrometry (TDMS)
approaches for protein analysis, driven both by technological advancements and efforts …
approaches for protein analysis, driven both by technological advancements and efforts …
The diverse and expanding role of mass spectrometry in structural and molecular biology
The emergence of proteomics has led to major technological advances in mass
spectrometry (MS). These advancements not only benefitted MS‐based high‐throughput …
spectrometry (MS). These advancements not only benefitted MS‐based high‐throughput …
Mass spectrometry of protein complexes: from origins to applications
Now routine is the ability to investigate soluble and membrane protein complexes in the gas
phase of a mass spectrometer while preserving folded structure and ligand-binding …
phase of a mass spectrometer while preserving folded structure and ligand-binding …
Approaches to heterogeneity in native mass spectrometry
Native mass spectrometry (MS) is aimed at preserving and determining the native structure,
composition, and stoichiometry of biomolecules and their complexes from solution after they …
composition, and stoichiometry of biomolecules and their complexes from solution after they …