Medical use of cannabinoids
Cannabinoid receptors, endocannabinoids and the enzymes responsible for their
biosynthesis and degradation constitute the endocannabinoid system. In recent decades …
biosynthesis and degradation constitute the endocannabinoid system. In recent decades …
The cannabinoid system and pain
Chronic pain states are highly prevalent and yet poorly controlled by currently available
analgesics, representing an enormous clinical, societal, and economic burden. Existing pain …
analgesics, representing an enormous clinical, societal, and economic burden. Existing pain …
Targeting the endocannabinoid system: to enhance or reduce?
As our understanding of the endocannabinoids improves, so does the awareness of their
complexity. During pathological states, the levels of these mediators in tissues change, and …
complexity. During pathological states, the levels of these mediators in tissues change, and …
An efficient randomised, placebo-controlled clinical trial with the irreversible fatty acid amide hydrolase-1 inhibitor PF-04457845, which modulates endocannabinoids …
JP Huggins, TS Smart, S Langman, L Taylor, T Young - PAIN®, 2012 - Elsevier
The effect of PF-04457845, a potent and selective fatty acid amide hydrolase-1 (FAAH1)
inhibitor, on pain due to osteoarthritis of the knee was investigated in a randomised placebo …
inhibitor, on pain due to osteoarthritis of the knee was investigated in a randomised placebo …
Enzymatic pathways that regulate endocannabinoid signaling in the nervous system
Chemical signals, or neurotransmitters, represent the fundamental mode for intercellular
communication in the nervous system. 1 The classical model for neurotransmitter action …
communication in the nervous system. 1 The classical model for neurotransmitter action …
The role of the endocannabinoid system in pain
Preparations of the Cannabis sativa plant have been used to analgesic effect for millenia,
but only in recent decades has the endogenous system responsible for these effects been …
but only in recent decades has the endogenous system responsible for these effects been …
Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain
Endocannabinoids are lipid signaling molecules that regulate a wide range of mammalian
behaviors, including pain, inflammation, and cognitive/emotional state. The …
behaviors, including pain, inflammation, and cognitive/emotional state. The …
[HTML][HTML] Cannabinoids as pharmacotherapies for neuropathic pain: from the bench to the bedside
Neuropathic pain is a debilitating form of chronic pain resulting from nerve injury, disease
states, or toxic insults. Neuropathic pain is often refractory to conventional …
states, or toxic insults. Neuropathic pain is often refractory to conventional …
Enhanced endocannabinoid tone as a potential target of pharmacotherapy
M Toczek, B Malinowska - Life sciences, 2018 - Elsevier
The endocannabinoid system is up-regulated in numerous pathophysiological states such
as inflammatory, neurodegenerative, gastrointestinal, metabolic and cardiovascular …
as inflammatory, neurodegenerative, gastrointestinal, metabolic and cardiovascular …