Cannabinoid receptors, endocannabinoids and the enzymes responsible for their
biosynthesis and degradation constitute the endocannabinoid system. In recent decades …

Chronic pain states are highly prevalent and yet poorly controlled by currently available
analgesics, representing an enormous clinical, societal, and economic burden. Existing pain …

The recent identification of cannabinoid receptors and their endogenous lipid ligands has
triggered an exponential growth of studies exploring the endocannabinoid system and its …

Endocannabinoids are lipid chemical mediators that act locally by activating cannabinoid
receptors of type 1 (CB 1) and type 2 (CB 2) receptors. The two most-studied …

The effect of PF-04457845, a potent and selective fatty acid amide hydrolase-1 (FAAH1)
inhibitor, on pain due to osteoarthritis of the knee was investigated in a randomised placebo …

Chemical signals, or neurotransmitters, represent the fundamental mode for intercellular
communication in the nervous system. 1 The classical model for neurotransmitter action …

Preparations of the Cannabis sativa plant have been used to analgesic effect for millenia,
but only in recent decades has the endogenous system responsible for these effects been …

Endocannabinoids are lipid signaling molecules that regulate a wide range of mammalian
behaviors, including pain, inflammation, and cognitive/emotional state. The …

Neuropathic pain is a debilitating form of chronic pain resulting from nerve injury, disease
states, or toxic insults. Neuropathic pain is often refractory to conventional …

Direct-acting cannabinoid receptor agonists are well known to reduce hyperalgesic
responses and allodynia after nerve injury, although their psychoactive side effects have …