The ATP‐binding cassette (ABC) transporter superfamily is one of the largest membrane
protein families existing in wide spectrum of organisms from prokaryotes to human. ABC …

Cancer remains a leading cause of morbidity and mortality worldwide. Hence, the increase
in cancer cases observed in the elderly population, as well as in children and adolescents …

Betulin is a kind of pentacyclic triterpenoid extracted from the bark of Betula platyphylla,
which has the characteristics of anti-inflammatory, antibacterial, antioxidant and so on …

Aims The overexpression of ABC transporters on cancer cell membranes is one of the most
common causes of multidrug resistance (MDR). This study investigates the impact of ABCC1 …

Multiple drug resistance (MDR) is characterized by the resistance of cancer cells to a broad
spectrum of anticancer drugs. The main mechanism underlying the MDR phenotype is the …

ATP-binding cassette (ABC) drug efflux transporters and drug metabolizing enzymes play
crucial roles in pharmacokinetic drug-drug interactions and multidrug tumor resistance …

Emerging evidence indicates that cancer cells can mimic characteristics of embryonic
development, promoting their development and progression. Cancer cells share features …

Malignant tumors contribute significantly to human mortality. Chemotherapy is a commonly
used treatment for tumors. However, due to the low selectivity of chemotherapeutic drugs …

In recent years, technical advances in chemotherapy and radiotherapy have helped
substantially improve the treatment outcome and quality of life of cancer patients …

Colorectal cancer (CRC) is a significant global health concern, posing a major threat to
morbidity and mortality rates. The molecular mechanisms that drive CRC, particularly the …