Amyloid β protein (Aβ) is the main component of neuritic plaques in Alzheimer's disease
(AD), and its accumulation has been considered as the molecular driver of Alzheimer's …

Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …

Alzheimer's disease (AD) is caused by synaptic and neuronal loss in the brain. One of the
characteristic hallmarks of AD is senile plaques containing amyloid β-peptide (Aβ). Aβ is …

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory loss
and personality changes, eventually leading to dementia. The pathological hallmarks of AD …

The so-called amyloid hypothesis, that the accumulation and deposition of oligomeric or
fibrillar amyloid β (Aβ) peptide is the primary cause of Alzheimer's disease (AD), has been …

Amyloid beta peptide (Aβ) is produced through the proteolytic processing of a
transmembrane protein, amyloid precursor protein (APP), by β-and γ-secretases. Aβ …

INTRODUCTION Alzheimer's disease (AD) is characterized by amyloid plaques in the brains
of patients. The primary components of amyloid plaques are β-amyloid peptides (Aβs) …

Alzheimer's disease (AD) is marked by the presence of extracellular amyloid beta (Aβ)
plaques, intracellular neurofibrillary tangles (NFTs) and gliosis, activated glial cells, in the …

Human γ-secretase is an intra-membrane protease that cleaves many different substrates.
Aberrant cleavage of Notch is implicated in cancer, while abnormalities in cutting amyloid …

Dysfunction of the intramembrane protease γ-secretase is thought to cause Alzheimer's
disease, with most mutations derived from Alzheimer's disease map** to the catalytic …