The most well-characterized organelle contact sites are those between the endoplasmic
reticulum (ER) and mitochondria. Increased understanding is being gained of how ER …

Mitochondria form a highly interconnected tubular network throughout the cell via a dynamic
process, with mitochondrial segments fusing and breaking apart continuously. Strong …

Aging is associated with changes in human brain anatomy and function and cognitive
decline. Recent studies suggest the aging decline of major functional connectivity hubs in …

Abstract The Greater Middle East (GME) has been a central hub of human migration and
population admixture. The tradition of consanguinity, variably practiced in the Persian Gulf …

Vigorous transport of cytoplasmic components along axons over substantial distances is
crucial for the maintenance of neuron structure and function. The transport of mitochondria …

The retromer complex is a vital element of the endosomal protein sorting machinery that is
conserved across all eukaryotes. Retromer is most closely associated with the endosome-to …

Hereditary spastic paraplegia (HSP) is a group of clinically and genetically heterogeneous
neurological disorders characterized by pathophysiologic hallmark of length-dependent …

Neuronal survival critically depends on the integrity and functionality of mitochondria. A
hierarchical system of cellular surveillance mechanisms protects mitochondria against …

Although the endoplasmic reticulum (ER) extends throughout axons and axonal ER
dysfunction is implicated in numerous neurological diseases, its role at nerve terminals is …

Hereditary spastic paraplegia comprises a wide and heterogeneous group of inherited
neurodegenerative and neurodevelopmental disorders resulting from primary retrograde …