Adrenocortical carcinoma (ACC) is a rare endocrine malignancy, often with an unfavorable
prognosis. Here we summarize the knowledge about diagnosis, epidemiology …

Novel immune checkpoint blockade with ipilimumab, an antibody blocking the cytotoxic T-
lymphocyte antigen 4 (CTLA4), is revolutionizing cancer therapy. However, ipilimumab …

Adrenal incidentalomas are adrenal masses detected on imaging performed for reasons
other than suspected adrenal disease. In most cases, adrenal incidentalomas are …

By definition, an adrenal incidentaloma is an asymptomatic adrenal mass detected on
imaging not performed for suspected adrenal disease. In most cases, adrenal …

Adrenocortical carcinoma (ACC) is a rare and in most cases steroid hormone-producing
tumor with variable prognosis. The purpose of these guidelines is to provide clinicians with …

Cushing's syndrome results from lengthy and inappropriate exposure to excessive
glucocorticoids. Untreated, it has significant morbidity and mortality. The syndrome remains …

BACKGROUND: The reported annual incidence of adrenocortical carcinoma (ACC) is 0.5–
2.0 cases per million individuals. Updated population-based studies on incidence are …

Adrenocortical carcinoma is a rare heterogeneous neoplasm with an incompletely
understood pathogenesis and a poor prognosis. Previous studies have identified …

Recent years have seen significant advances in our understanding of the development and
function of the adrenal gland together with further insights into the physiologic and …

Origin of the adrenogonadal primordium The adrenal glands develop from 2 separate
embryologic tissues: the medulla is derived from neural crest cells originating in proximity to …