Electrogenesis in the heart begins in the sinoatrial node and proceeds down the conduction
system to originate the heartbeat. Conduction system disorders lead to slow heart rates that …

The WNT/β‐catenin pathway is a master regulator of cardiac development and growth, and
its activity is low in healthy adult hearts. However, even this low activity is essential for …

Despite the success of current therapies for acute myocardial infarction (MI), many patients
still develop adverse cardiac remodeling and heart failure. With the growing prevalence of …

We have prepared and tested in vivo a novel nanoengineered hybrid electroconductive
cardiac patch for treating the infarcted myocardium. Of the prepared and tested patches, only …

Glycogen synthase kinase 3β (GSK3) is a multifaceted serine/threonine (S/T) kinase
expressed in all eukaryotic cells. GSK3β is highly enriched in neurons in the central nervous …

Relaxin is a hormone of pregnancy first discovered for its ability to induce ligament
relaxation in nonpregnant guinea pig and is important for softening of the birth canal during …

The intercalated discs that connect cardiomyocytes control cell-to-cell adhesion and
communication. Several macromolecular structures (desmosomes, fascia adherens …

Background Mutations in the cardiac sodium channel gene SCN5A cause Brugada
syndrome (BrS), an arrhythmic disorder that is a leading cause of sudden death and lacks …

Healthy aging results in cardiac structural and electrical remodeling that increases
susceptibility to cardiovascular diseases. Relaxin, an insulin-like hormone, suppresses atrial …

Oxidants and canonical Wnt/β-catenin signaling have been shown to decrease cardiac Na+
channel activity by suppressing Na V 1.5 expression. Our aims are to determine if hydrogen …