Antibiotic resistance is a major global health challenge and, worryingly, several key Gram
negative pathogens can become resistant to most currently available antibiotics. Polymyxins …

After the first aminoglycoside antibiotic streptomycin being applied in clinical practice in the
mid-1940s, aminoglycoside antibiotics (AGAs) are widely used to treat clinical bacterial …

A depleted antimicrobial drug pipeline combined with an increasing prevalence of Gram-
negative 'superbugs' has increased interest in nano therapies to treat antibiotic resistance …

Introduction The increasing prevalence of infections with multidrug-resistant (MDR),
extensively-drug resistant (XDR) or difficult-to-treat drug resistant (DTR) Gram-negative …

Antibiotic resistance presents an incessant threat to our drug armamentarium that
necessitates novel approaches to therapy. Over the past several decades, investigation of …

Antibiotic abuse is becoming increasingly serious and the potential for harm to human
health and the environment has aroused widespread social concern. Aminoglycoside …

Protocatechuic acid (PCA) has adequate antibacterial activity against foodborne pathogens;
however, its antibacterial mechanism has been rarely investigated. Therefore, this study …

Due to the threat of escalating multi-drug resistant gram-negative bacteria to human health
and life, novel antimicrobial agents against gram-negative pathogens are urgently needed …

The increasing incidence of bacterial infections caused by multidrug-resistant (MDR) Gram-
negative bacteria has deepened the need for new effective treatments. Antibiotic adjuvant …

The rapid dissemination of antibiotic resistance accelerates the desire for new antibacterial
agents. Here, a class of antimicrobial peptides (AMPs) is designed by modifying the …