Single nucleotide polymorphism arrays (SNP-A) have recently been widely applied as a
powerful karyoty** tool in numerous translational cancer studies. SNP-A complements …

Complex functioning of the genome in the cell nucleus is controlled at different levels:(a) the
DNA base sequence containing all relevant inherited information;(b) epigenetic pathways …

Background Fragile sites are the chromosomal regions that are susceptible to breakage,
and their frequency varies among the human population. Based on the frequency of fragile …

Low-risk myelodysplastic syndrome (MDS) with normal cytogenetics accounts for
approximately 50% of MDS patients. There are no pathognomonic markers in these cases …

Since the first description of human fragile sites (FS) more than 40 years ago, a variety of
substances were reported to induce chromosomal breaks at non-random, breakage-prone …

The systematic application of new genome-wide single nucleotide polymorphism arrays has
demonstrated that somatically acquired regions of loss of heterozygosity without changes in …

Considerable advances have been made in our understanding of the molecular basis of
hematopoietic cancers. The discovery of the BCR-ABL fusion protein over 50 years ago has …

The majority of malignant tumors exhibit complex genomic aberrations, and it has been
suggested that an elevated rate of chromosome mutation is present in neoplastic cells. This …

Human cells contain various repetitive DNA sequences, which can be a challenge for the
DNA replication machinery to travel through and replicate correctly. Repetitive DNA …

Lymphocytes are unique among cells in that they undergo programmed DNA breaks and
translocations, but that special property predisposes them to chromosomal instability (CIN) …