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SARS-CoV-2: from its discovery to genome structure, transcription, and replication
SARS-CoV-2 is an extremely contagious respiratory virus causing adult atypical pneumonia
COVID-19 with severe acute respiratory syndrome (SARS). SARS-CoV-2 has a single …
COVID-19 with severe acute respiratory syndrome (SARS). SARS-CoV-2 has a single …
Two years into the COVID-19 pandemic: lessons learned
SJR da Silva, JCF do Nascimento… - ACS infectious …, 2022 - ACS Publications
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible
and virulent human-infecting coronavirus that emerged in late December 2019 in Wuhan …
and virulent human-infecting coronavirus that emerged in late December 2019 in Wuhan …
The role of NSP6 in the biogenesis of the SARS-CoV-2 replication organelle
S Ricciardi, AM Guarino, L Giaquinto, EV Polishchuk… - Nature, 2022 - nature.com
Abstract SARS-CoV-2, like other coronaviruses, builds a membrane-bound replication
organelle to enable RNA replication. The SARS-CoV-2 replication organelle is composed of …
organelle to enable RNA replication. The SARS-CoV-2 replication organelle is composed of …
TMPRSS2 expression dictates the entry route used by SARS‐CoV‐2 to infect host cells
J Koch, ZM Uckeley, P Doldan, M Stanifer… - The EMBO …, 2021 - embopress.org
SARS‐CoV‐2 is a newly emerged coronavirus that caused the global COVID‐19 outbreak in
early 2020. COVID‐19 is primarily associated with lung injury, but many other clinical …
early 2020. COVID‐19 is primarily associated with lung injury, but many other clinical …
ACE2-dependent and-independent SARS-CoV-2 entries dictate viral replication and inflammatory response during infection
Excessive inflammation is the primary cause of mortality in patients with severe COVID-19,
yet the underlying mechanisms remain poorly understood. Our study reveals that ACE2 …
yet the underlying mechanisms remain poorly understood. Our study reveals that ACE2 …
[HTML][HTML] Mutations in SARS-CoV-2: Insights on structure, variants, vaccines, and biomedical interventions
COVID-19 is a worldwide pandemic caused by SARS-coronavirus-2 (SARS-CoV-2). Less
than a year after the emergence of the Covid-19 pandemic, many vaccines have arrived on …
than a year after the emergence of the Covid-19 pandemic, many vaccines have arrived on …
Main protease mutants of SARS-CoV-2 variants remain susceptible to nirmatrelvir
The COVID-19 pandemic continues to be a public health threat. Multiple mutations in the
spike protein of emerging variants of SARS-CoV-2 appear to impact on the effectiveness of …
spike protein of emerging variants of SARS-CoV-2 appear to impact on the effectiveness of …
Innate immune sensing of coronavirus and viral evasion strategies
The innate immune system is the first line of the host defense program against pathogens
and harmful substances. Antiviral innate immune responses can be triggered by multiple …
and harmful substances. Antiviral innate immune responses can be triggered by multiple …
[HTML][HTML] ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formation
G Miao, H Zhao, Y Li, M Ji, Y Chen, Y Shi, Y Bi… - Developmental cell, 2021 - cell.com
Autophagy acts as a cellular surveillance mechanism to combat invading pathogens.
Viruses have evolved various strategies to block autophagy and even subvert it for their …
Viruses have evolved various strategies to block autophagy and even subvert it for their …
Structures and functions of coronavirus replication–transcription complexes and their relevance for SARS-CoV-2 drug design
B Malone, N Urakova, EJ Snijder… - … Reviews Molecular Cell …, 2022 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has killed millions of
people and continues to cause massive global upheaval. Coronaviruses are positive-strand …
people and continues to cause massive global upheaval. Coronaviruses are positive-strand …