SARS-CoV-2: from its discovery to genome structure, transcription, and replication

AC Brant, W Tian, V Majerciak, W Yang, ZM Zheng - Cell & bioscience, 2021 - Springer
SARS-CoV-2 is an extremely contagious respiratory virus causing adult atypical pneumonia
COVID-19 with severe acute respiratory syndrome (SARS). SARS-CoV-2 has a single …

Two years into the COVID-19 pandemic: lessons learned

SJR da Silva, JCF do Nascimento… - ACS infectious …, 2022 - ACS Publications
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible
and virulent human-infecting coronavirus that emerged in late December 2019 in Wuhan …

The role of NSP6 in the biogenesis of the SARS-CoV-2 replication organelle

S Ricciardi, AM Guarino, L Giaquinto, EV Polishchuk… - Nature, 2022 - nature.com
Abstract SARS-CoV-2, like other coronaviruses, builds a membrane-bound replication
organelle to enable RNA replication. The SARS-CoV-2 replication organelle is composed of …

TMPRSS2 expression dictates the entry route used by SARS‐CoV‐2 to infect host cells

J Koch, ZM Uckeley, P Doldan, M Stanifer… - The EMBO …, 2021 - embopress.org
SARS‐CoV‐2 is a newly emerged coronavirus that caused the global COVID‐19 outbreak in
early 2020. COVID‐19 is primarily associated with lung injury, but many other clinical …

ACE2-dependent and-independent SARS-CoV-2 entries dictate viral replication and inflammatory response during infection

T Duan, C **ng, J Chu, X Deng, Y Du, X Liu, Y Hu… - Nature cell …, 2024 - nature.com
Excessive inflammation is the primary cause of mortality in patients with severe COVID-19,
yet the underlying mechanisms remain poorly understood. Our study reveals that ACE2 …

[HTML][HTML] Mutations in SARS-CoV-2: Insights on structure, variants, vaccines, and biomedical interventions

AI Abulsoud, HM El-Husseiny, AA El-Husseiny… - Biomedicine & …, 2023 - Elsevier
COVID-19 is a worldwide pandemic caused by SARS-coronavirus-2 (SARS-CoV-2). Less
than a year after the emergence of the Covid-19 pandemic, many vaccines have arrived on …

Main protease mutants of SARS-CoV-2 variants remain susceptible to nirmatrelvir

S Ullrich, KB Ekanayake, G Otting, C Nitsche - Bioorganic & medicinal …, 2022 - Elsevier
The COVID-19 pandemic continues to be a public health threat. Multiple mutations in the
spike protein of emerging variants of SARS-CoV-2 appear to impact on the effectiveness of …

Innate immune sensing of coronavirus and viral evasion strategies

Y Kasuga, B Zhu, KJ Jang, JS Yoo - Experimental & molecular medicine, 2021 - nature.com
The innate immune system is the first line of the host defense program against pathogens
and harmful substances. Antiviral innate immune responses can be triggered by multiple …

[HTML][HTML] ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formation

G Miao, H Zhao, Y Li, M Ji, Y Chen, Y Shi, Y Bi… - Developmental cell, 2021 - cell.com
Autophagy acts as a cellular surveillance mechanism to combat invading pathogens.
Viruses have evolved various strategies to block autophagy and even subvert it for their …

Structures and functions of coronavirus replication–transcription complexes and their relevance for SARS-CoV-2 drug design

B Malone, N Urakova, EJ Snijder… - … Reviews Molecular Cell …, 2022 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has killed millions of
people and continues to cause massive global upheaval. Coronaviruses are positive-strand …