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CD8+ T cells in the cancer-immunity cycle
CD8+ T cells are end effectors of cancer immunity. Most forms of effective cancer
immunotherapy involve CD8+ T cell effector function. Here, we review the current …
immunotherapy involve CD8+ T cell effector function. Here, we review the current …
Epigenetic regulation of T cell exhaustion
Chronic antigen stimulation during viral infections and cancer can lead to T cell exhaustion,
which is characterized by reduced effector function and proliferation, and the expression of …
which is characterized by reduced effector function and proliferation, and the expression of …
[HTML][HTML] CD8+ T cell activation in cancer comprises an initial activation phase in lymph nodes followed by effector differentiation within the tumor
Improvements in tumor immunotherapies depend on better understanding of the anti-tumor
T cell response. By studying human tumor-draining lymph nodes (TDLNs), we found that …
T cell response. By studying human tumor-draining lymph nodes (TDLNs), we found that …
Transcriptional signatures associated with persisting CD19 CAR-T cells in children with leukemia
In the context of relapsed and refractory childhood pre-B cell acute lymphoblastic leukemia
(R/R B-ALL), CD19-targeting chimeric antigen receptor (CAR)-T cells often induce durable …
(R/R B-ALL), CD19-targeting chimeric antigen receptor (CAR)-T cells often induce durable …
[HTML][HTML] An NK-like CAR T cell transition in CAR T cell dysfunction
Chimeric antigen receptor (CAR) T cell therapy has achieved remarkable success in
hematological malignancies but remains ineffective in solid tumors, due in part to CAR T cell …
hematological malignancies but remains ineffective in solid tumors, due in part to CAR T cell …
Hallmarks of CD8+ T cell dysfunction are established within hours of tumor antigen encounter before cell division
Tumor-specific CD8+ T cells (TST) in patients with cancer are dysfunctional and unable to
halt cancer progression. TST dysfunction, also known as exhaustion, is thought to be driven …
halt cancer progression. TST dysfunction, also known as exhaustion, is thought to be driven …
CD8+ T Cell Exhaustion in Cancer
JS Dolina, N Van Braeckel-Budimir… - Frontiers in …, 2021 - frontiersin.org
A paradigm shift in the understanding of the exhausted CD8+ T cell (Tex) lineage is
underway. Originally thought to be a uniform population that progressively loses effector …
underway. Originally thought to be a uniform population that progressively loses effector …
[HTML][HTML] MYB orchestrates T cell exhaustion and response to checkpoint inhibition
CD8+ T cells that respond to chronic viral infections or cancer are characterized by the
expression of inhibitory receptors such as programmed cell death protein 1 (PD-1) and by …
expression of inhibitory receptors such as programmed cell death protein 1 (PD-1) and by …
'Stem-like' precursors are the fount to sustain persistent CD8+ T cell responses
D Zehn, R Thimme, E Lugli, GP de Almeida… - Nature …, 2022 - nature.com
Virus-specific CD8+ T cells that differentiate in the context of resolved versus persisting
infections exhibit divergent phenotypic and functional characteristics, which suggests that …
infections exhibit divergent phenotypic and functional characteristics, which suggests that …
[HTML][HTML] Spatiotemporal co-dependency between macrophages and exhausted CD8+ T cells in cancer
T cell exhaustion is a major impediment to antitumor immunity. However, it remains elusive
how other immune cells in the tumor microenvironment (TME) contribute to this dysfunctional …
how other immune cells in the tumor microenvironment (TME) contribute to this dysfunctional …