CD8+ T cells in the cancer-immunity cycle

JR Giles, AM Globig, SM Kaech, EJ Wherry - Immunity, 2023 - cell.com
CD8+ T cells are end effectors of cancer immunity. Most forms of effective cancer
immunotherapy involve CD8+ T cell effector function. Here, we review the current …

Epigenetic regulation of T cell exhaustion

JA Belk, B Daniel, AT Satpathy - Nature immunology, 2022 - nature.com
Chronic antigen stimulation during viral infections and cancer can lead to T cell exhaustion,
which is characterized by reduced effector function and proliferation, and the expression of …

[HTML][HTML] CD8+ T cell activation in cancer comprises an initial activation phase in lymph nodes followed by effector differentiation within the tumor

N Prokhnevska, MA Cardenas, RM Valanparambil… - Immunity, 2023 - cell.com
Improvements in tumor immunotherapies depend on better understanding of the anti-tumor
T cell response. By studying human tumor-draining lymph nodes (TDLNs), we found that …

Transcriptional signatures associated with persisting CD19 CAR-T cells in children with leukemia

ND Anderson, J Birch, T Accogli, I Criado… - Nature Medicine, 2023 - nature.com
In the context of relapsed and refractory childhood pre-B cell acute lymphoblastic leukemia
(R/R B-ALL), CD19-targeting chimeric antigen receptor (CAR)-T cells often induce durable …

[HTML][HTML] An NK-like CAR T cell transition in CAR T cell dysfunction

CR Good, MA Aznar, S Kuramitsu, P Samareh… - Cell, 2021 - cell.com
Chimeric antigen receptor (CAR) T cell therapy has achieved remarkable success in
hematological malignancies but remains ineffective in solid tumors, due in part to CAR T cell …

Hallmarks of CD8+ T cell dysfunction are established within hours of tumor antigen encounter before cell division

MW Rudloff, P Zumbo, NR Favret, JJ Roetman… - Nature …, 2023 - nature.com
Tumor-specific CD8+ T cells (TST) in patients with cancer are dysfunctional and unable to
halt cancer progression. TST dysfunction, also known as exhaustion, is thought to be driven …

CD8+ T Cell Exhaustion in Cancer

JS Dolina, N Van Braeckel-Budimir… - Frontiers in …, 2021 - frontiersin.org
A paradigm shift in the understanding of the exhausted CD8+ T cell (Tex) lineage is
underway. Originally thought to be a uniform population that progressively loses effector …

[HTML][HTML] MYB orchestrates T cell exhaustion and response to checkpoint inhibition

C Tsui, L Kretschmer, S Rapelius, SS Gabriel… - Nature, 2022 - nature.com
CD8+ T cells that respond to chronic viral infections or cancer are characterized by the
expression of inhibitory receptors such as programmed cell death protein 1 (PD-1) and by …

'Stem-like' precursors are the fount to sustain persistent CD8+ T cell responses

D Zehn, R Thimme, E Lugli, GP de Almeida… - Nature …, 2022 - nature.com
Virus-specific CD8+ T cells that differentiate in the context of resolved versus persisting
infections exhibit divergent phenotypic and functional characteristics, which suggests that …

[HTML][HTML] Spatiotemporal co-dependency between macrophages and exhausted CD8+ T cells in cancer

K Kersten, KH Hu, AJ Combes, B Samad, T Harwin… - Cancer Cell, 2022 - cell.com
T cell exhaustion is a major impediment to antitumor immunity. However, it remains elusive
how other immune cells in the tumor microenvironment (TME) contribute to this dysfunctional …