CD8+ T cell differentiation and dysfunction in cancer
M Philip, A Schietinger - Nature Reviews Immunology, 2022 - nature.com
CD8+ T cells specific for cancer cells are detected within tumours. However, despite their
presence, tumours progress. The clinical success of immune checkpoint blockade and …
presence, tumours progress. The clinical success of immune checkpoint blockade and …
Not-so-opposite ends of the spectrum: CD8+ T cell dysfunction across chronic infection, cancer and autoimmunity
CD8+ T cells are critical mediators of cytotoxic effector function in infection, cancer and
autoimmunity. In cancer and chronic viral infection, CD8+ T cells undergo a progressive loss …
autoimmunity. In cancer and chronic viral infection, CD8+ T cells undergo a progressive loss …
[HTML][HTML] Cancer immunotherapy: opportunities and challenges in the rapidly evolving clinical landscape
Cancer immunotherapy is now established as a powerful way to treat cancer. The recent
clinical success of immune checkpoint blockade (antagonists of CTLA-4, PD-1 and PD-L1) …
clinical success of immune checkpoint blockade (antagonists of CTLA-4, PD-1 and PD-L1) …
Tolerance and exhaustion: defining mechanisms of T cell dysfunction
A Schietinger, PD Greenberg - Trends in immunology, 2014 - cell.com
CD8 T cell activation and differentiation are tightly controlled, and dependent on the context
in which naïve T cells encounter antigen, can either result in functional memory or T cell …
in which naïve T cells encounter antigen, can either result in functional memory or T cell …
Persistent antigen at vaccination sites induces tumor-specific CD8+ T cell sequestration, dysfunction and deletion
Y Hailemichael, Z Dai, N Jaffarzad, Y Ye, MA Medina… - Nature medicine, 2013 - nature.com
To understand why cancer vaccine–induced T cells often do not eradicate tumors, we
studied immune responses in mice vaccinated with gp100 melanoma peptide in incomplete …
studied immune responses in mice vaccinated with gp100 melanoma peptide in incomplete …
PD-1 maintains CD8 T cell tolerance towards cutaneous neoantigens
The peripheral T cell repertoire of healthy individuals contains self-reactive T cells,.
Checkpoint receptors such as PD-1 are thought to enable the induction of peripheral …
Checkpoint receptors such as PD-1 are thought to enable the induction of peripheral …
Molecular and translational classifications of DAMPs in immunogenic cell death
The immunogenicity of malignant cells has recently been acknowledged as a critical
determinant of efficacy in cancer therapy. Thus, besides develo** direct …
determinant of efficacy in cancer therapy. Thus, besides develo** direct …
CD4+ T-Cell Help in the Tumor Milieu Is Required for Recruitment and Cytolytic Function of CD8+ T Lymphocytes
R Bos, LA Sherman - Cancer research, 2010 - AACR
Abstract CD4 help for CD8+ T lymphocytes prevents tolerance and promotes the survival of
effector and memory CD8+ T cells. Here, we describe additional helper functions that …
effector and memory CD8+ T cells. Here, we describe additional helper functions that …
Dendritic cells in a mature age
C Reis e Sousa - Nature Reviews Immunology, 2006 - nature.com
A common view supposes that dendritic cells (DCs) exist in two basic functional states:
immature DCs induce tolerance to self, whereas mature DCs induce immunity to foreign …
immature DCs induce tolerance to self, whereas mature DCs induce immunity to foreign …
Heterogeneity and cell-fate decisions in effector and memory CD8+ T cell differentiation during viral infection
Heterogeneity is a hallmark of the adaptive immune system. This is most evident in the
enormous diversity of B and T cell antigen receptors. There is also heterogeneity within …
enormous diversity of B and T cell antigen receptors. There is also heterogeneity within …