m6A modification: recent advances, anticancer targeted drug discovery and beyond

LJ Deng, WQ Deng, SR Fan, MF Chen, M Qi, WY Lyu… - Molecular cancer, 2022 - Springer
Abstract Abnormal N6-methyladenosine (m6A) modification is closely associated with the
occurrence, development, progression and prognosis of cancer, and aberrant m6A …

The role of m6A RNA methylation in human cancer

XY Chen, J Zhang, JS Zhu - Molecular cancer, 2019 - Springer
Abstract N 6-methyladenosine (m 6 A) is identified as the most common, abundant and
conserved internal transcriptional modification, especially within eukaryotic messenger …

The RNA modification N6-methyladenosine as a novel regulator of the immune system

Z Shulman, N Stern-Ginossar - Nature immunology, 2020 - nature.com
Protection from harmful pathogens depends on activation of the immune system, which
relies on tight regulation of gene expression. Recently, the RNA modification N 6 …

FTO m6A demethylase in obesity and cancer: implications and underlying molecular mechanisms

SK Azzam, H Alsafar, AA Sa**i - International journal of molecular …, 2022 - mdpi.com
Fat mass and obesity-associated protein (FTO) is the first reported RNA N6-
methyladenosine (m6A) demethylase in eukaryotic cells. m6A is considered as the most …

The emerging roles of N6-methyladenosine (m6A) deregulation in liver carcinogenesis

M Chen, CM Wong - Molecular cancer, 2020 - Springer
Liver cancer is a common cancer worldwide. Although the etiological factors of liver
carcinogenesis are well defined, the underlying molecular mechanisms remain largely …

[HTML][HTML] Dysregulated m6A modification promotes lipogenesis and development of non-alcoholic fatty liver disease and hepatocellular carcinoma

Y Yang, J Cai, X Yang, K Wang, K Sun, Z Yang… - Molecular Therapy, 2022 - cell.com
Type 2 diabetes mellitus (DM2) is associated closely with non-alcoholic fatty liver disease
(NAFLD) by affecting lipid metabolism, which may lead to non-alcoholic steatohepatitis …

N6-methyladenosine-mediated gene regulation and therapeutic implications

Y Liu, D Yang, T Liu, J Chen, J Yu, P Yi - Trends in molecular medicine, 2023 - cell.com
Abstract N6-methyladenosine (m 6 A) RNA methylation is the most abundant form of mRNA
modification in eukaryotes and is at the front line of biological and biomedical research. This …

Surmounting cancer drug resistance: New insights from the perspective of N6-methyladenosine RNA modification

B Li, J Jiang, YG Assaraf, H **ao, ZS Chen… - Drug resistance …, 2020 - Elsevier
Despite the development of targeted therapy, drug resistance remains a primary hindrance
to curative treatment of various cancers. Among several novel approaches to overcome drug …

Orthogonal demethylase-activated deoxyribozyme for intracellular imaging and gene regulation

Q Wang, K Tan, H Wang, J Shang, Y Wan… - Journal of the …, 2021 - ACS Publications
The epigenetic modification of nucleic acids represents a versatile approach for achieving
high-efficient control over gene expression and transcription and could dramatically expand …

FTO–a common genetic basis for obesity and cancer

N Lan, Y Lu, Y Zhang, S Pu, H **, X Nie, J Liu… - Frontiers in …, 2020 - frontiersin.org
In recent years, the prevalence of obesity and cancer have been rising. Since this poses a
serious threat to human health, the relationship between the two has attracted much …