m6A modification: recent advances, anticancer targeted drug discovery and beyond
LJ Deng, WQ Deng, SR Fan, MF Chen, M Qi, WY Lyu… - Molecular cancer, 2022 - Springer
Abstract Abnormal N6-methyladenosine (m6A) modification is closely associated with the
occurrence, development, progression and prognosis of cancer, and aberrant m6A …
occurrence, development, progression and prognosis of cancer, and aberrant m6A …
The role of m6A RNA methylation in human cancer
XY Chen, J Zhang, JS Zhu - Molecular cancer, 2019 - Springer
Abstract N 6-methyladenosine (m 6 A) is identified as the most common, abundant and
conserved internal transcriptional modification, especially within eukaryotic messenger …
conserved internal transcriptional modification, especially within eukaryotic messenger …
The RNA modification N6-methyladenosine as a novel regulator of the immune system
Protection from harmful pathogens depends on activation of the immune system, which
relies on tight regulation of gene expression. Recently, the RNA modification N 6 …
relies on tight regulation of gene expression. Recently, the RNA modification N 6 …
FTO m6A demethylase in obesity and cancer: implications and underlying molecular mechanisms
Fat mass and obesity-associated protein (FTO) is the first reported RNA N6-
methyladenosine (m6A) demethylase in eukaryotic cells. m6A is considered as the most …
methyladenosine (m6A) demethylase in eukaryotic cells. m6A is considered as the most …
The emerging roles of N6-methyladenosine (m6A) deregulation in liver carcinogenesis
Liver cancer is a common cancer worldwide. Although the etiological factors of liver
carcinogenesis are well defined, the underlying molecular mechanisms remain largely …
carcinogenesis are well defined, the underlying molecular mechanisms remain largely …
[HTML][HTML] Dysregulated m6A modification promotes lipogenesis and development of non-alcoholic fatty liver disease and hepatocellular carcinoma
Y Yang, J Cai, X Yang, K Wang, K Sun, Z Yang… - Molecular Therapy, 2022 - cell.com
Type 2 diabetes mellitus (DM2) is associated closely with non-alcoholic fatty liver disease
(NAFLD) by affecting lipid metabolism, which may lead to non-alcoholic steatohepatitis …
(NAFLD) by affecting lipid metabolism, which may lead to non-alcoholic steatohepatitis …
N6-methyladenosine-mediated gene regulation and therapeutic implications
Abstract N6-methyladenosine (m 6 A) RNA methylation is the most abundant form of mRNA
modification in eukaryotes and is at the front line of biological and biomedical research. This …
modification in eukaryotes and is at the front line of biological and biomedical research. This …
Surmounting cancer drug resistance: New insights from the perspective of N6-methyladenosine RNA modification
Despite the development of targeted therapy, drug resistance remains a primary hindrance
to curative treatment of various cancers. Among several novel approaches to overcome drug …
to curative treatment of various cancers. Among several novel approaches to overcome drug …
Orthogonal demethylase-activated deoxyribozyme for intracellular imaging and gene regulation
Q Wang, K Tan, H Wang, J Shang, Y Wan… - Journal of the …, 2021 - ACS Publications
The epigenetic modification of nucleic acids represents a versatile approach for achieving
high-efficient control over gene expression and transcription and could dramatically expand …
high-efficient control over gene expression and transcription and could dramatically expand …
FTO–a common genetic basis for obesity and cancer
N Lan, Y Lu, Y Zhang, S Pu, H **, X Nie, J Liu… - Frontiers in …, 2020 - frontiersin.org
In recent years, the prevalence of obesity and cancer have been rising. Since this poses a
serious threat to human health, the relationship between the two has attracted much …
serious threat to human health, the relationship between the two has attracted much …