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Artificial intelligence and machine learning technology driven modern drug discovery and development
The discovery and advances of medicines may be considered as the ultimate relevant
translational science effort that adds to human invulnerability and happiness. But advancing …
translational science effort that adds to human invulnerability and happiness. But advancing …
Machine learning in drug discovery: a review
This review provides the feasible literature on drug discovery through ML tools and
techniques that are enforced in every phase of drug development to accelerate the research …
techniques that are enforced in every phase of drug development to accelerate the research …
[HTML][HTML] In vitro models replicating the human intestinal epithelium for absorption and metabolism studies: A systematic review
Absorption, distribution, metabolism and excretion (ADME) studies represent a fundamental
step in the early stages of drug discovery. In particular, the absorption of orally administered …
step in the early stages of drug discovery. In particular, the absorption of orally administered …
The pharmacological efficacy of baicalin in inflammatory diseases
Y Wen, Y Wang, C Zhao, B Zhao, J Wang - International journal of …, 2023 - mdpi.com
Baicalin is one of the most abundant flavonoids found in the dried roots of Scutellaria
baicalensis Georgi (SBG) belonging to the genus Scutellaria. While baicalin is demonstrated …
baicalensis Georgi (SBG) belonging to the genus Scutellaria. While baicalin is demonstrated …
Toxicity testing in the 21st century: progress in the past decade and future perspectives
Advances in the biological sciences have led to an ongoing paradigm shift in toxicity testing
based on expanded application of high-throughput in vitro screening and in silico methods …
based on expanded application of high-throughput in vitro screening and in silico methods …
[HTML][HTML] Microfluidic organ-on-a-chip models of human intestine
Microfluidic organ-on-a-chip models of human intestine have been developed and used to
study intestinal physiology and pathophysiology. In this article, we review this field and …
study intestinal physiology and pathophysiology. In this article, we review this field and …
Pharmaceutical strategies of improving oral systemic bioavailability of curcumin for clinical application
Z Ma, N Wang, H He, X Tang - Journal of Controlled Release, 2019 - Elsevier
Curcumin (Cur), a natural compound from Curcuma longa Linn, has various of
pharmacological activities such as anti-cancer, anti-inflammatory, anti-oxidant, anti …
pharmacological activities such as anti-cancer, anti-inflammatory, anti-oxidant, anti …
Therapeutic potentials of baicalin and its aglycone, baicalein against inflammatory disorders
B Dinda, S Dinda, S DasSharma, R Banik… - European journal of …, 2017 - Elsevier
Abstract The flavonoids, baicalin (5, 6-dihydroxy-2-phenyl-4H-1-benzopyran-4-one-7-Od-β-
glucuronic acid) 1 and its aglycone, baicalein 2 are found in edible medicinal plants …
glucuronic acid) 1 and its aglycone, baicalein 2 are found in edible medicinal plants …
An overview of in vitro, ex vivo and in vivo models for studying the transport of drugs across intestinal barriers
Oral administration is the most commonly used route for drug delivery owing to its cost-
effectiveness, ease of administration, and high patient compliance. However, the absorption …
effectiveness, ease of administration, and high patient compliance. However, the absorption …
Butyrate-producing bacteria supplemented in vitro to Crohn's disease patient microbiota increased butyrate production and enhanced intestinal epithelial barrier …
The management of the dysbiosed gut microbiota in inflammatory bowel diseases (IBD) is
gaining more attention as a novel target to control this disease. Probiotic treatment with …
gaining more attention as a novel target to control this disease. Probiotic treatment with …