Many recent advances have emerged in the telomere and telomerase fields. This Timeline
article highlights the key advances that have expanded our views on the mechanistic …

The genomes of prokaryotes and eukaryotic organelles are usually circular as are most
plasmids and viral genomes. In contrast, the nuclear genomes of eukaryotes are organized …

The ends of eukaryotic chromosomes have the potential to be mistaken for damaged or
broken DNA and must therefore be protected from cellular DNA damage response …

The mechanism by which telomeres prevent end-to-end fusion has remained elusive. Here,
we show that the human telomeric protein TRF2 plays a key role in the protective activity of …

Cell cycle checkpoints are regulatory pathways that control the order and timing of cell cycle
transitions and ensure that critical events such as DNA replication and chromosome …

Eukaryotic genomes are highly complex and divided into linear chromosomes that require
end protection from unwarranted fusions, recombination, and degradation in order to …

Telomeres, the ends of linear eukaryotic chromosomes, are characterized by the presence
of multiple repeats of a short DNA sequence. This telomeric DNA is protected from illicit …

Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome
termini in most eukaryotes. Telomerase RNA components have been identified from many …

Telomeres with G-rich repetitive DNA and particular proteins as special heterochromatin
structures at the termini of eukaryotic chromosomes are tightly maintained to safeguard …

The chromosomes of lower eukaryotes have short telomeric 3′ extensions. Using a primer-
extension/nick-translation technique and nondenaturing hybridization, we find long 3′ G …