The causative agent of tuberculosis (TB), Mycobacterium tuberculosis and more recently
totally drug‐resistant strains of M. tuberculosis, display unique mechanisms to survive in the …

The ribosome is a major target for clinically used antibiotics, but multidrug resistant
pathogenic bacteria are making our current arsenal of antimicrobials obsolete. Here we …

The extent of ribosomal heterogeneity has caught increasing interest over the past few
years, as recent studies have highlighted the presence of structural variations of the …

The ribosome exit tunnel is an important structure involved in the regulation of translation
and other essential functions such as protein folding. By comparing 20 recently obtained …

The proline-rich antimicrobial peptide (PrAMP) drosocin is produced by Drosophila species
to combat bacterial infection. Unlike many PrAMPs, drosocin is O-glycosylated at threonine …

Bacteria respond to zinc starvation by replacing ribosomal proteins that have the zinc-
binding CXXC motif (C+) with their zinc-free (C−) paralogues. Consequences of this process …

Ribosomes translate RNA into proteins. The protein synthesis inhibitor cycloheximide (CHX)
is widely used to inhibit eukaryotic ribosomes engaged in translation elongation. However …

Ribosome hibernation is a key survival strategy bacteria adopt under environmental stress,
where a protein, hibernation promotion factor (HPF), transitorily inactivates the ribosome …

The antibiotic linezolid, the first clinically approved member of the oxazolidinone class,
inhibits translation of bacterial ribosomes by binding to the peptidyl transferase center …

Acne vulgaris is a chronic disfiguring skin disease affecting∼ 1 billion people worldwide,
often having persistent negative effects on physical and mental health. The Gram-positive …