ABC family transporters
X Liu - Drug transporters in drug disposition, effects and …, 2019 - Springer
The transport of specific molecules across lipid membranes is an essential function of all
living organisms. The processes are usually mediated by specific transporters. One of the …
living organisms. The processes are usually mediated by specific transporters. One of the …
Heme in pathophysiology: a matter of scavenging, metabolism and trafficking across cell membranes
Heme (iron-protoporphyrin IX) is an essential co-factor involved in multiple biological
processes: oxygen transport and storage, electron transfer, drug and steroid metabolism …
processes: oxygen transport and storage, electron transfer, drug and steroid metabolism …
Structure and function of ABCA4 and its role in the visual cycle and Stargardt macular degeneration
RS Molday, FA Garces, JF Scortecci… - Progress in retinal and eye …, 2022 - Elsevier
ABCA4 is a member of the superfamily of ATP-binding cassette (ABC) transporters that is
preferentially localized along the rim region of rod and cone photoreceptor outer segment …
preferentially localized along the rim region of rod and cone photoreceptor outer segment …
ABC transporters as cancer drivers: Potential functions in cancer development
Background ABC transporters have attracted considerable attention for their function as drug
transporters in a broad range of tumours and are therefore considered as major players in …
transporters in a broad range of tumours and are therefore considered as major players in …
The ABCG2 Q141K hyperuricemia and gout associated variant illuminates the physiology of human urate excretion
KM Hoque, EE Dixon, RM Lewis, J Allan… - Nature …, 2020 - nature.com
The pathophysiological nature of the common ABCG2 gout and hyperuricemia associated
variant Q141K (rs2231142) remains undefined. Here, we use a human interventional cohort …
variant Q141K (rs2231142) remains undefined. Here, we use a human interventional cohort …
Tyrosine kinase inhibitors as modulators of ABC transporter-mediated drug resistance
Tyrosine kinases (TKs) are involved in key signaling events/pathways that regulate cancer
cell proliferation, apoptosis, angiogenesis and metastasis. Deregulated activity of TKs has …
cell proliferation, apoptosis, angiogenesis and metastasis. Deregulated activity of TKs has …
Lesinurad, a novel, oral compound for gout, acts to decrease serum uric acid through inhibition of urate transporters in the kidney
JN Miner, PK Tan, D Hyndman, S Liu, C Iverson… - Arthritis research & …, 2016 - Springer
Background Excess body burden of uric acid promotes gout. Diminished renal clearance of
uric acid causes hyperuricemia in most patients with gout, and the renal urate transporter …
uric acid causes hyperuricemia in most patients with gout, and the renal urate transporter …
[HTML][HTML] Current advances on ABC drug transporters in fish
Most members of the large ATP-binding cassette (ABC) gene family are transporters
involved in substrate translocation across biological membranes. In eukaryotes, ABC …
involved in substrate translocation across biological membranes. In eukaryotes, ABC …
The half‐size ABC transporters STR1 and STR2 are indispensable for mycorrhizal arbuscule formation in rice
C Gutjahr, D Radovanovic, J Geoffroy… - The Plant …, 2012 - Wiley Online Library
The central structure of the symbiotic association between plants and arbuscular mycorrhizal
(AM) fungi is the fungal arbuscule that delivers minerals to the plant. Our earlier …
(AM) fungi is the fungal arbuscule that delivers minerals to the plant. Our earlier …
Sex differences in urate handling
VL Halperin Kuhns, OM Woodward - International journal of molecular …, 2020 - mdpi.com
Hyperuricemia, or elevated serum urate, causes urate kidney stones and gout and also
increases the incidence of many other conditions including renal disease, cardiovascular …
increases the incidence of many other conditions including renal disease, cardiovascular …