The formation of new blood vessels, or angiogenesis, is a complex process that plays
important roles in growth and development, tissue and organ regeneration, as well as …

Tortuous arteries and veins are commonly observed in humans and animals. While mild
tortuosity is asymptomatic, severe tortuosity can lead to ischemic attack in distal organs …

Angiogenesis is initiated in response to a variety of external cues, including mechanical and
biochemical stimuli; however, the underlying signaling mechanisms remain unclear. Here …

We examined the role of MCP-1, a potent chemotactic and activating factor for
macrophages, in perfusion, inflammation, and skeletal muscle regeneration post-ischemic …

Pericytes are perivascular cells that envelop and make intimate connections with adjacent
capillary endothelial cells. Recent studies show that they may have a profound impact in …

Chemokines recruit inflammatory cells to sites of injury, but the role of the CC chemokine
receptor 2 (CCR2) during regenerative processes following ischemia is poorly understood …

Rationale Appropriate ischemia models are required for successful studies of therapeutic
angiogenesis. While collateral routes are known to be present within the innate vasculature …

OBJECTIVE: To identify the optimal mouse model for hind limb ischaemia, which offers a
therapeutic window that is large enough to detect improvements of blood flow recovery, for …

Peripheral arterial disease (PAD) develops due to the narrowing or blockage of arteries
supplying blood to the lower limbs. Surgical and endovascular interventions are the main …

Arteries are under significant mechanical loads from blood pressure, flow, tissue tethering,
and body movement. It is critical that arteries remain patent and stable under these loads …