Genome-wide association studies (GWASs) have focused primarily on populations of
European descent, but it is essential that diverse populations become better represented …

Recent technological advances have expanded the breadth of available omic data, from
whole-genome sequencing data, to extensive transcriptomic, methylomic and metabolomic …

A polygenic risk score estimates the genetic risk of an individual for some disease or trait,
calculated by aggregating the effect of many common variants associated with the condition …

Advanced age-related macular degeneration (AMD) is the leading cause of blindness in the
elderly, with limited therapeutic options. Here we report on a study of> 12 million variants …

Candidate gene and genome-wide association studies (GWAS) have identified genetic
variants that modulate risk for human disease; many of these associations require further …

Variance-component methods that estimate the aggregate contribution of large sets of
variants to the heritability of complex traits have yielded important insights into the genetic …

Mendelian randomization (MR) harnesses genetic variants as instrumental variables (IVs) to
study the causal effect of exposure on outcome using summary statistics from genome-wide …

Polycystic ovary syndrome (PCOS) is a common, highly heritable complex disorder of
unknown aetiology characterized by hyperandrogenism, chronic anovulation and defects in …

The presence of duplicates introduced by PCR amplification is a major issue in paired short
reads from next-generation sequencing platforms. These duplicates might have a serious …

New races of Puccinia striiformis f. sp. tritici (Pst), the causal pathogen of wheat stripe rust,
show high virulence to previously deployed resistance genes and are responsible for large …