Idiopathic intracranial hypertension: a step change in understanding the disease mechanisms

A Yiangou, SP Mollan, AJ Sinclair - Nature Reviews Neurology, 2023 - nature.com
The understanding of idiopathic intracranial hypertension (IIH) has evolved over the past few
years. Previously, IIH was considered a disease exclusively affecting the neuro-ophthalmic …

Ten open questions in migraine prophylaxis with monoclonal antibodies blocking the calcitonin-gene related peptide pathway: a narrative review

J Schoenen, A Van Dycke, J Versijpt… - The Journal of Headache …, 2023 - Springer
The monoclonal antibodies (mAbs) blocking the calcitonin-gene related peptide (CGRP)
pathway, collectively called here “anti-CGRP/rec mAbs”, have dramatically improved …

Hypersensitivity to PACAP-38 in post-traumatic headache: a randomized clinical trial

HM Al-Khazali, RH Christensen, DW Dodick… - Brain, 2024 - academic.oup.com
Pituitary adenylate cyclase-activating polypeptide-38 (PACAP-38), known for its role in
migraine pathogenesis, has been identified as a novel drug target. Given the clinical …

Preclinical studies of posttraumatic headache and the potential therapeutics

M Tanaka, Y Zhang - Cells, 2022 - mdpi.com
Posttraumatic headache (PTH) attributed to traumatic brain injury (TBI) is a secondary
headache developed within 7 days after head injury, and in a substantial number of patients …

What traditional neuropsychological assessment got wrong about mild traumatic brain injury. II: limitations in test development, research design, statistical and …

ED Bigler, S Allder, J Victoroff - Brain Injury, 2024 - Taylor & Francis
ABSTRACT Primary Objective This is Part II of a four-part opinion review on traditional
neuropsychological assessment methods and findings associated with mild traumatic brain …

Inhibition of 2-AG hydrolysis alleviates posttraumatic headache attributed to mild traumatic brain injury

J Wen, M Tanaka, Y Zhang - The Journal of Headache and Pain, 2024 - Springer
Background Posttraumatic headache (PTH) is a common and debilitating symptom following
repetitive mild traumatic brain injury (rmTBI), and it mainly resembles a migraine-like …

Repeat mild traumatic brain injuries (RmTBI) modify nociception and disrupt orexinergic connectivity within the descending pain pathway

J Christensen, N MacPherson, C Li… - The Journal of …, 2023 - Springer
Repeat mild traumatic brain injuries (RmTBI) result in substantial burden to the public health
system given their association with chronic post-injury pathologies, such as chronic pain and …

Serum calcitonin gene-related peptide in patients with persistent post-concussion symptoms, including headache: a cohort study

PP Eggertsen, J Palmfeldt, HW Schytz, D Hay… - Journal of …, 2024 - Springer
Background Calcitonin gene-related peptide (CGRP) plays an important role in migraine
pathophysiology, and post-traumatic headache (PTH) frequently presents with migraine-like …

Conservative management of acute sports-related concussions: a narrative review

S Kureshi, M Mendizabal, J Francis, HR Djalilian - Healthcare, 2024 - mdpi.com
This review explores the application of the conservative management model for pain to
sports-related concussions (SRCs), framing concussions as a distinct form of pain syndrome …

Developments in targeting calcitonin gene-related peptide

S Alabbad, N Figueredo, H Yuan… - Expert Review of …, 2024 - Taylor & Francis
ABSTRACT Introduction Calcitonin Gene-Related Peptide (CGRP)-targeted therapy has
revolutionized migraine treatment since its first approval in 2018. CGRP-targeted therapy …